Submission of a photograph of eccrine chromhidrosis.
What is Eccrine Chromhidrosis?
Eccrine chromhidrosis is defined by the secretion of colored sweat originating from the nodes eccrine sweat glands [1]. These glands are widely distributed throughout the body, although they are notably concentrated in the palms of the hands and the soles of the feet, playing an essential role in the body's thermoregulation.
Population Affected by Eccrine Chromhidrosis
This disorder is considered rare and can manifest at any point in life, affecting individuals of both sexes equally [2].
Underlying Causes of Eccrine Chromhidrosis
The etiologies that can lead to eccrine chromhidrosis include several factors [1,2]:
- The presence of granules. of lipofuscin granules, presumably originating from the oxidation of unsaturated fatty acids.
- The ingestion the ingestion of various medications, metals, and dyes; this includes laxatives coated with tartrazine (bisacodyl), quinine, rifampicin, clofazimine, methylene blue, mercury, and copper.
- Excessive consumption of beta-carotene, known as carotenemia..
- Hyperbilirubinemia.
- Uremia.
Clinical Characteristics of Eccrine Chromhidrosis
Although eccrine chromhidrosis can manifest in any area of the body, symptoms usually intensify in the palms and soles, areas with a higher density of eccrine glands. eccrine glands. The color spectrum of the emitted sweat is wide, including red, blue, orange, brown, yellow, green, black, and white tones, depending on the responsible chemical, medication, or dye [1–4].
It is common for patients to experience a localized sensation of heat or itching on the affected skin immediately before the emission of colored sweat.
Differential Diagnosis of Eccrine Chromhidrosis
To establish a definitive diagnosis, the spectrum of disorders to consider includes:
- Pseudochromhidrosis.
- Chromhidrosis apocrine.
- Eczema vesicular of the hands.
- HIV by Pseudomonas.
Diagnostic Methods for Eccrine Chromhidrosis
Eccrine chromhidrosis is usually diagnosed through clinical evaluation, but certain procedures can confirm the finding [1,2]:
- Dermoscopy, Dermoscopy, used to evaluate the location and nature of the in the skin include several biochemical processes:.
- Skin Hematological and serological analyses commonly reveal the following patterns:.
- Analysis of liver and kidney function.
- Skin scraping and culture mucosal biopsy bacteria chromogenic bacteria (a common cause of pseudochromhidrosis).
- Wood's lamp examination Wood's lamp examination with a Wood's lamp to differentiate it from apocrine chromhidrosis, which may exhibit yellow fluorescence.
Treatment and Expectations Prognosis of Eccrine Chromhidrosis
The prognosis for this condition is usually excellent as long as the causative agent or the dye responsible for the coloration can be identified and eradicated.
