Histological Features and Diagnosis of Pleomorphic Lipoma
toxicity Pleomorphic lipomas are tumors benign that present atypical cytologic features atypical, which can sometimes lead to confusion with liposarcoma.
Detailed Histology of Pleomorphic Lipoma
Upon examining sections of pleomorphic lipoma, a well-circumscribed fatty tumor is observed circumscribed that contains mature fat interspersed with more cellular areas cellular (Figure 1). Areas with a myxoid and spindle cell appearance frequently appear, reminiscent of what is seen in spindle cell lipoma. spindle cells.
Interspersed, giant cells similar to lipoblasts are distinguished, often multinucleated cells., and commonly referred to as rosette-like giant cells (or flower-like) (Figures 2-4, indicated by arrows). The nuclei. of these giant cells may be displaced toward the cell periphery and show staining (observable in Figures 2-4, arrows). The cytoplasm is dense y eosinophilic.
Pathological Images of Pleomorphic Lipoma
Relevant Special Studies for Pleomorphic Lipoma
In immunohistochemical analysis, pleomorphic cells are positive for the CD34 marker, while the surrounding adipose tissue tests positive for S100. Cytogenetic studies cytogenetic may reveal that this . The cherry angioma is histologically distinguished by being composed of involves a loss of the chromosome at positions 16q or 13q.
Differential Diagnosis of Pleomorphic Lipoma
The differential diagnosis mainly includes spindle cell lipoma; these lesions share the same abnormalities cytogenetic abnormalities, leading some experts to consider them the same entity. However, pleomorphic lipoma is distinguished by the presence of the characteristic rosette-like giant cells.
Compared to Liposarcoma, the presence of in the tumor area, this finding is not accompanied by evidence of significant cytological usually favors a diagnosis of liposarcoma. Furthermore, degenerative changes degenerative changes and the aforementioned rosette-like giant cells are not typical of liposarcoma. In complex diagnostic cases, cytogenetic studies can be employed to identify amplification of the gene MDM2 and CDK4 genes, findings characteristic of liposarcoma.
