Clinical Forms and Histology of Angiofibroma

There are different clinical manifestations of angiofibroma that, despite their superficial differences, share an identical histopathology. These forms include:

• Fibrous papule
• Papules of the pearly penile papules
• Angiofibroma associated with systemic sclerosis tuberous
• Syndromic Angiofibroma.

Detailed Histology of Angiofibroma

Angiofibromas typically present as a dome-shaped mass on the surface of the dermis (Figure 1). The epidermis overlying epidermis is generally not affected, although it may show signs of limb. The distinctive feature of this lesion is the proliferation proliferation of spindle and stellate cells surrounding the blood vessels blood vessels collagen coarse collagen bundles arranged in a concentric manner (Figures 1, 2). A useful diagnostic resource is comparing the collagen density of the lesion with the surrounding dermis, which often appears looser or with elastic damage. In some cases, a sparse infiltrate of squamous inflammatory inflammatory cell infiltrate composed of lymphocytes lymphocytes.

can be identified. Histological evaluation has allowed for the description of several important subtypes:

• The hypercellular angiofibroma is distinguished by a higher density of the spindle and stellate fibroblasts present (Figure 3).
• The clear cell variant exhibits a proliferation of foamy and , measuring 3 to 10 μm, within these myofibroblasts (highlighted in Figures 2 through 4)., granular cells, with an appearance reminiscent of histiocytes. and a smaller proportion of histiocytes..
• The pleomorphic is characterized by the presence of cells stellate fibroblasts with unusual morphology.
• Finally, the epithelioid epithelioid variant cytoplasm of the angiofibroma is composed of cells with epithelioid features, highlighting a pink cytoplasm and prominent nucleoli.

Figure 1

Figure 2

figure 3