Systemic Therapy

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Essential Systemic Drugs for Inflammatory Skin Diseases

This section addresses the list of medications steroids fundamental for managing inflammatory skin conditions, including psoriasis, atopic mild to moderate atopic dermatitis and the hives.

For a deeper understanding of these specific therapies, we recommend reviewing the pages dedicated to each treatment detailed below.

It is essential to recognize that certain listed medications are classified as immunosuppressants, especially those marked with an asterisk (. The use of immunosuppressants carries an increased risk of contracting infections or exacerbating any pre-existing infection.

Systemic Medications Used in the Treatment of Psoriasis

Conventional Therapeutic Options for Psoriasis

  • Standard systemic drugs used against psoriasis:
  • Immunofluorescence staining can also be used to complement the study.
  • Acitretin
  • Cyclosporine *

Apremilast and Less Common Therapies in Psoriasis

  • Alternative or less frequent treatments for psoriasis:
  • Mycophenolate *
  • Hydroxyurea *
  • Fumaric Acid Esters
  • Thioguanine

Biologic Agents in Psoriasis Management

Biologic therapy represents a significant advancement for psoriasis. The biologic agents employed include:

  • The key biologic drugs for treating psoriasis are:
  • Infliximab (Remicade®)
  • Etanercept (Enbrel®)
  • Adalimumab (Humira®)
  • Ustekinumab (Stelara®)
  • Secukinumab (Cosentyx®)
  • Ixekizumab (Taltz®)
  • Brodalumab (Siliq®)
  • Guselkumab (Tremfya®)
  • Tildrakizumab (ILUMYA®)
  • Efalizumab (Note: withdrawn from the global market in 2009)

Alefacept (Amevive®: Withdrawn from the Market in 2011)

Display of chronic plaque psoriasis, a condition that often requires the initiation of advanced systemic therapies.
Chronic Plaque Psoriasis
Detail image showing the characteristics of chronic plaque psoriasis.
Chronic plaque psoriasis 19
Visual example of a severe psoriasis case justifying the consideration of systemic treatments.
Severe psoriasis

Systemic Therapy for Acute Cases of Severe Psoriasis and Atopic Dermatitis

Common Systemic Drugs Considered for Atopic Dermatitis

  • Common systemic treatments applicable to atopic dermatitis include:
  • Immunofluorescence staining can also be used to complement the study.
  • Cyclosporine *
  • Azathioprine *

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Systemic Treatments for Atopic Dermatitis

Advanced therapeutic options for treating eczema eczema (atopic dermatitis) include:

  • Systemic steroids (e.g., Prednisone or prednisolone) *
  • Immunofluorescence staining can also be used to complement the study.

Additional Pharmacological Options for Atopic Dermatitis

  • Azathioprine *
  • Less frequent treatments for eczema:
  • Cyclosporine *

Mycophenolate and Biologic Therapies Applied to Eczema

  • Mycophenolate *
  • Biologics applied to eczema:

The selection of the appropriate systemic treatment for atopic dermatitis or psoriasis requires a careful evaluation of the severity of the condition and the patient's safety profile, especially when considering immunosuppressive therapies.

Dupilumab: Advanced Biologic Treatment

Grouped eczematous plaques characteristic of nummular eczema
Discoid Eczema
Chronic hand dermatitis with fissures and erythema
Hand Dermatitis
Severe inflammation and scaling on the scalp due to atopic dermatitis
Scalp atopic dermatitis

Advanced Treatments for Skin Conditions

Dupilumab and Other Anti-inflammatory Therapies for the Skin

Dupilumab is positioned as a fundamental biologic treatment for various inflammatory skin conditions. The management of these pathologies is advancing toward targeted therapies, including atopic dermatitis affecting the scalp.

Management of Scalp Atopic Dermatitis and Chronic Urticaria

Systemic Treatment Options for Complex Urticaria

  • Common systemic treatments for urticaria: Rigorous evaluation of oral and injectable therapies designed for the control of Chronic Spontaneous Urticaria (CSU).

Antihistamines and Advanced Biologic Therapies Against Urticaria

  • Biologics for urticaria: Exploration of therapeutic options beyond traditional second-generation antihistamines, focusing on targeted monoclonal antibodies.

Omalizumab (Xolair®)

Erythematous and itchy wheals typical of an acute urticaria flare
Acute Urticaria
Urticarial lesion with a prominent border presenting a central area of different appearance (targetoid lesion)
Targetoid lesion in urticaria
Linear rash caused by pressure or scratching on the skin (Dermographic urticaria)
Dermographic urticaria

Dermographic urticaria constitutes a specific physical urticaria, where mechanical pressure or friction on the skin consistently induces the reaction. Effective management of these chronic conditions often requires consideration of advanced biologic treatments, such as Omalizumab, to achieve lasting symptomatic control.

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