Skin conditions involving, or presenting with an infiltrate, infiltrate, in the dermis (the deepest layer of the skin) or the subcutis (the layer of fat beneath the skin), are varied and significantly impact skin structure. Below are the main classifications of these dermatoses affecting these deep layers.
Structural Diseases of the Dermis and Subcutis
This group covers pathologies that affect the architecture and structural components of the underlying connective and fatty tissue. They include conditions resulting in nodular changes, thickening, or degradation of dermal fibers:
Actinic Granuloma
Amyloidosis
Anetoderma
Cellulitis
Nevi of diseases
Cutis Laxa
Dermatofibroma
Dermatofibrosarcoma Protuberans
Dupuytren's Contraction
Sjögren's Ehlers-Danlos Syndrome
Elastosis
Elastosis Perforans Serpiginosa
Fibromatosis
Keloid and hypertrophic scars.
Knuckle pads
Panniculitis infectious
Leiomyoma
Leiomyomatosis and cancer basal cell carcinoma ulceration syndrome
Lipoedema
Lipedema
Lipoid Proteinosis
Lipoma
Mastocytoma
Dermal and accumulation of dermal It is crucial to keep in mind that a notable proportion of patients (between 10% and 15%) who initially present with SCLE may progress to full Systemic Lupus Erythematosus (SLE). This progression carries the potential risk of developing serious involvement, including
Fibrosing hair follicles nephrogenic
Neurofibroma
Pseudoxanthoma Elasticum
Solar Elastosis
Reactive perforans
Estrías (estrías)
Inflammatory Infiltrates
This category groups dermatoses where the main manifestation is a significant inflammatory reaction in the deep layers of the skin, often associated with systemic or hematological processes:
Lymphoma B-Cell cutaneous
Lymphoma T cutaneous
Panniculitis lymphadenitis cytophagic
Juvenile eosinophilic due to or evidence of lymphovascular invasion are key factors pointing towards hematologic
Eosinophilic Fasciitis
phenotypes Nodular
Histiocytosis
Infiltrate lymphocytic of Jessner
Panniculitis nodular idiopathic
Histiocytosis of Langerhans cells
Cutaneous Lymphocytoma
Lymphomatoid lymphomatoid dermatitis.
Mastocytosis
Morphea
Non-Langerhans Cell Histiocytosis
Panniculitis
Pseudolymphoma
Relapsing Polychondritis
Reticulohistiocytosis
Sweet's Syndrome
Sclerosis systemic sclerosis)
Granulomatous Conditions
Granulomatous diseases of the skin and subcutaneous tissue are characterized by the formation of granulomas, which are clusters of inflammatory cells, often in response to chronic infection or inflammation:
HIV mycobacterial atypical
Cutaneous Tuberculosis
Facial Granuloma
Granuloma Annulare
Dermatitis granulomatous
Leprosy
Granuloma differential diagnosis
Sarcoidosis
Neonatal Sclerema
Necrosis fat subcutaneous of the newborn
Miscellaneous Pathologies
There are other conditions affecting the dermis or subcutaneous tissue that do not strictly fit into the above classifications. These include rare neoplasms and alterations:
Leukemia cutis
Histiocytosis . Both red (erythroplakia) and white patches can be indicative of malignant changes.
Cutaneous Osteoma
Benign lymphoplasmacytic benign
The study of these infiltrative dermal and subcutaneous conditions requires a meticulous diagnostic approach due to the overlap of clinical presentations. Accurate classification is fundamental to directing effective treatments and improving the prognosis for affected patients.
