Invasive Squamous Cell Carcinoma (SCC)
Invasive Squamous Cell Carcinoma (SCC) in the anogenital region is fundamentally classified according to its primary location. These are the main classification categories based on the site of origin:
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Squamous Cell Carcinoma of the Penis
- Verrucous Squamous Cell Carcinoma of the Penis
- Squamous Cell Carcinoma of the Scrotum
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Squamous Cell Carcinoma of the Vulva
- Verrucous Squamous Cell Carcinoma of the Vulva
- Squamous Cell Carcinoma of the Vagina
- Anal Carcinoma, including squamous cell carcinoma of the anal margin.
Precursor Lesions: Squamous Cell Carcinoma In Situ
When Squamous Cell Carcinoma In Situ is related to a Human Papillomavirus (HPV) infection, it is called high-grade squamous intraepithelial lesion (HSIL). Specific types of HSIL include:
- Penile Intraepithelial Neoplasia (PIN)
- Vulvar Intraepithelial Neoplasia (VIN)
- Vaginal Intraepithelial Neoplasia (VAIN)
- Anal Intraepithelial Neoplasia (AIN)
- Bowenoid Papulosis.


