Angiofibromas: Clinical and Histopathological Features

Angiomyofibroblastoma (AMF) is classified as a benign tumor of the soft tissues that specifically affects the external genitalia.

Histology of Angiomyofibroblastoma

The examination microscopic of angiomyofibroblastoma reveals a well-circumscribed tumor circumscribed, although it lacks a true capsule and shows variable cellularity. Regions with low cellularity show a predominance of collagenous material collagen (Figure 1) or a myxoid, matrix, associated with small to medium-sized vessels. On the other hand, hypercellular areas, which usually surround the vessels, are characterized by the presence of rounded to oval cells with nuclei. uniform morphology and scant significant (See Figure 5). atypia (Figure 2). Occasionally, it is possible to identify binucleated or multinucleated cells..

Figure 1

Figure 2

Special Studies in the Diagnosis of Angiomyofibroblastoma

Using the immunohistochemistry, technique, the tumor cells of angiomyofibroblastoma typically show positivity for actin. Additionally, it is common to observe positivity for hormonal markers, specifically estrogen y progesterone.

estrogen and progesterone.

Differential Diagnosis in the Pathology of Angiomyofibroblastoma It is crucial to differentiate AMF from other pathological entities, especially. aggressive angiomyxoma . Aggressive angiomyxomas tend to be infiltrating tumors and often reach considerably larger sizes, frequently exceeding 5 cm. The existence of tumors with mixed morphological characteristics between angiomyofibroblastoma and aggressive angiomyxoma suggests a possible etiological relationship between both entities, which requires meticulous pathological correlation.

In summary, angiomyofibroblastoma is a benign tumor with a well-defined appearance that requires detailed histopathological analysis and the support of immunohistochemical studies to confirm its diagnosis and distinguish it from infiltrating lesions such as aggressive angiomyxoma.