{"id":14107,"date":"2020-11-21T05:55:13","date_gmt":"2020-11-21T05:55:13","guid":{"rendered":"https:\/\/dermatly.com\/patologia-del-adenocarcinoma-metastasico\/"},"modified":"2026-03-10T16:59:27","modified_gmt":"2026-03-10T16:59:27","slug":"pathologie-van-metastatisch-adenocarcinoom","status":"publish","type":"glossary","link":"https:\/\/dermatly.com\/nl\/patologia-del-adenocarcinoma-metastasico\/","title":{"rendered":"Pathologie van metastatisch adenocarcinoom"},"content":{"rendered":"
\n

Histologie van metastatisch adenocarcinoom in de huid<\/h1>\n

Bij het onderzoeken van de histologie van metastatisch adenocarcinoom worden vaak verschillende morfologische patronen waargenomen. Bij lage vergroting is het gebruikelijk een tumor te identificeren afgebakende<\/span> die de dermis infiltreert lymfocyten<\/span> (Figuur 1). Macroscopisch worden strengen<\/span> y noduli<\/span> bestaande uit atypische epitheelcellen Het is belangrijk op te merken dat op het oppervlak van een zonne-lentigo \u00e9\u00e9n of meer<\/span> die zich een weg banen tussen de collageenbundels collageen<\/span> (Figuur 2). Deze formaties kunnen tekenen van buis- of klierformatie vertonen klieren<\/span> (Figuur 3), en soms ingebed gevonden worden in een stroom<\/span> mucineus stroma (Figuur 4). Bij de angiectatische en erysipelato\u00efde vormen van borstmetastasen kan vasculaire en lymfatische invasie opvallend zijn. metastase<\/span> borstmetastasen, kan vasculaire en lymfatische invasie opvallend zijn. vasculair<\/span> y lymfatische<\/span>.<\/p>\n

\n

Pathologie van metastatisch adenocarcinoom<\/h2>\n<\/section>\n
\n
\n
\n \"Microscopie\n <\/div>\n

Figuur 1<\/p>\n

\n \"Microscopie\n <\/div>\n

Figuur 2<\/p>\n

\n \"Microscopie\n <\/div>\n

Figuur 3<\/p>\n

\n \"Microscopie\n <\/div>\n

Figuur 4<\/p>\n<\/p><\/div>\n<\/section>\n<\/section>\n

<\/div>\n
\n

Speciale kleuringen en differentiaaldiagnose van metastatisch adenocarcinoom<\/h2>\n

Hoewel klinische correlatie en adequate stadi\u00ebring onvervangbaar zijn bij oncologische evaluatie, biedt de laag.<\/span> (IHC) vitale hulpmiddelen om de primaire oorsprong te suggereren en deze laesies te onderscheiden van primaire huidappendagetumoren. Huidgerelateerde effecten<\/span> CK7<\/span> Tumoren primair<\/span>. Hieronder worden de algemene kleuringsrichtlijnen uiteengezet, hoewel men moet onthouden dat deze markers nooit absoluut specifiek zijn voor de differentiaaldiagnose: differentiaaldiagnose<\/span>:<\/p>\n

    \n
  • P63:<\/strong> Toont vaker positiviteit bij primaire huidappendagetumoren.<\/li>\n
  • CK7- \/ CK20 +:<\/strong> Sugereert sterk een gastro-intestinale oorsprong.<\/li>\n
  • CK7 + \/ CK20-:<\/strong> Meer suggestief voor een pulmonale oorsprong.<\/li>\n
  • CK7:<\/strong> Een focale kleuring kan wijzen op een primaire huidappendagetumor, in tegenstelling tot een sterke en diffuse kleuring diffuse<\/span> die metastatisch adenocarcinoom suggereert.<\/li>\n
  • CK 5\/6:<\/strong> Negatieve kleuring wordt relatief zelden waargenomen bij primaire huidtumoren.<\/li>\n
  • CDX2:<\/strong> Positiviteit wijst op een mogelijke gastro-intestinale oorsprong.<\/li>\n
  • Villin:<\/strong> Richtinggevend voor een gastro-intestinale, pancreatische of galweg oorsprong. galwegen<\/span>.<\/li>\n
  • ER, PR en GCDFP:<\/strong> Deze markers zijn gunstig voor een mammaire oorsprong. Het is cruciaal op te merken dat ze allemaal tot expressie kunnen komen in primaire appendagelaesies en bovendien kunnen metastatische laesies dit kleuringsvermogen verliezen. laesies<\/span> metastatische laesies kunnen dit kleuringsvermogen verliezen.<\/li>\n
  • Mammaglobine:<\/strong> Diffuse kleuring wijst op een metastase van mammaire oorsprong, hoewel verspreide positiviteit kan worden waargenomen bij primaire huidappendagetumoren.<\/li>\n
  • PSA en prostaat-specifiek fosfatase<\/span> (PAP):<\/strong> Ondersteunen een prostaat-oorsprong voor de metastase.<\/li>\n
  • Podoplanine (D240):<\/strong> Negatieve kleuring suggereert meestal een laesie laesie<\/span> die geen lymfangiosarcoommetastase is (hoewel de context adenocarcinoom is, wordt deze marker klassiek gebruikt in dit differentiaaldiagnose).<\/li>\n<\/ul>\n

    Zorgvuldige interpretatie van deze immunohistochemische profielen, in correlatie met de cellulaire morfologie en de klinische context van de pati\u00ebnt, is essentieel voor het vaststellen van een definitieve diagnose en het starten van de juiste oncologische behandeling.<\/p>\n<\/section>","protected":false},"excerpt":{"rendered":"

    Histolog\u00eda del Adenocarcinoma Metast\u00e1sico en la Piel Al examinar la histolog\u00eda del adenocarcinoma metast\u00e1sico, frecuentemente se observan diversos patrones morfol\u00f3gicos. A baja potencia, es com\u00fan identificar un tumor circunscrito que infiltra la dermis (Figura 1). Macrosc\u00f3picamente, se aprecian cordones y n\u00f3dulos compuestos por c\u00e9lulas at\u00edpicas del epitelio, las cuales se abren paso entre los haces […]<\/p>\n","protected":false},"author":1,"featured_media":14112,"parent":0,"template":"","glossary-cat":[],"class_list":["post-14107","glossary","type-glossary","status-publish","has-post-thumbnail","hentry"],"yoast_head":"\nPatolog\u00eda del adenocarcinoma metast\u00e1sico - Dermatly.com - El sitio de tu piel<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/dermatly.com\/nl\/pathologie-van-metastatisch-adenocarcinoom\/\" \/>\n<meta property=\"og:locale\" content=\"nl_NL\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Patolog\u00eda del adenocarcinoma metast\u00e1sico\" \/>\n<meta property=\"og:description\" content=\"Histolog\u00eda del Adenocarcinoma Metast\u00e1sico en la Piel Al examinar la histolog\u00eda del adenocarcinoma metast\u00e1sico, frecuentemente se observan diversos patrones morfol\u00f3gicos. A baja potencia, es com\u00fan identificar un tumor circunscrito que infiltra la dermis (Figura 1). Macrosc\u00f3picamente, se aprecian cordones y n\u00f3dulos compuestos por c\u00e9lulas at\u00edpicas del epitelio, las cuales se abren paso entre los haces […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/dermatly.com\/nl\/pathologie-van-metastatisch-adenocarcinoom\/\" \/>\n<meta property=\"og:site_name\" content=\"Dermatly.com - El sitio de tu piel\" \/>\n<meta property=\"article:modified_time\" content=\"2026-03-10T16:59:27+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/dermatly.com\/wp-content\/uploads\/2020\/11\/figure1metastaticadeno__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-2705924.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"294\" \/>\n\t<meta property=\"og:image:height\" content=\"222\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Geschatte leestijd\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minuten\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/dermatly.com\/patologia-del-adenocarcinoma-metastasico\/\",\"url\":\"https:\/\/dermatly.com\/patologia-del-adenocarcinoma-metastasico\/\",\"name\":\"Patolog\u00eda del adenocarcinoma metast\u00e1sico - Dermatly.com - El sitio de tu piel\",\"isPartOf\":{\"@id\":\"https:\/\/dermatly.com\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/dermatly.com\/patologia-del-adenocarcinoma-metastasico\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/dermatly.com\/patologia-del-adenocarcinoma-metastasico\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/dermatly.com\/wp-content\/uploads\/2020\/11\/figure1metastaticadeno__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-2705924.jpg\",\"datePublished\":\"2020-11-21T05:55:13+00:00\",\"dateModified\":\"2026-03-10T16:59:27+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/dermatly.com\/patologia-del-adenocarcinoma-metastasico\/#breadcrumb\"},\"inLanguage\":\"nl-NL\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/dermatly.com\/patologia-del-adenocarcinoma-metastasico\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"nl-NL\",\"@id\":\"https:\/\/dermatly.com\/patologia-del-adenocarcinoma-metastasico\/#primaryimage\",\"url\":\"https:\/\/dermatly.com\/wp-content\/uploads\/2020\/11\/figure1metastaticadeno__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-2705924.jpg\",\"contentUrl\":\"https:\/\/dermatly.com\/wp-content\/uploads\/2020\/11\/figure1metastaticadeno__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-2705924.jpg\",\"width\":294,\"height\":222,\"caption\":\"figure1metastaticadeno__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-2705924-8718964-jpg-6114455\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/dermatly.com\/patologia-del-adenocarcinoma-metastasico\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/dermatly.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Glossary\",\"item\":\"https:\/\/dermatly.com\/glossary\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Patolog\u00eda del adenocarcinoma metast\u00e1sico\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/dermatly.com\/#website\",\"url\":\"https:\/\/dermatly.com\/\",\"name\":\"Dermatly.com - El sitio de tu piel\",\"description\":\"Dermatolog\u00eda y lesiones de la piel\",\"publisher\":{\"@id\":\"https:\/\/dermatly.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/dermatly.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"nl-NL\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/dermatly.com\/#organization\",\"name\":\"dermatly.com\",\"url\":\"https:\/\/dermatly.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"nl-NL\",\"@id\":\"https:\/\/dermatly.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/dermatly.com\/wp-content\/uploads\/2020\/11\/dermatly-logo.png\",\"contentUrl\":\"https:\/\/dermatly.com\/wp-content\/uploads\/2020\/11\/dermatly-logo.png\",\"width\":448,\"height\":110,\"caption\":\"dermatly.com\"},\"image\":{\"@id\":\"https:\/\/dermatly.com\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Pathologie van metastatisch adenocarcinoom - Dermatly.com - De site voor uw huid","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/dermatly.com\/nl\/pathologie-van-metastatisch-adenocarcinoom\/","og_locale":"nl_NL","og_type":"article","og_title":"Patolog\u00eda del adenocarcinoma metast\u00e1sico","og_description":"Histolog\u00eda del Adenocarcinoma Metast\u00e1sico en la Piel Al examinar la histolog\u00eda del adenocarcinoma metast\u00e1sico, frecuentemente se observan diversos patrones morfol\u00f3gicos. A baja potencia, es com\u00fan identificar un tumor circunscrito que infiltra la dermis (Figura 1). Macrosc\u00f3picamente, se aprecian cordones y n\u00f3dulos compuestos por c\u00e9lulas at\u00edpicas del epitelio, las cuales se abren paso entre los haces […]","og_url":"https:\/\/dermatly.com\/nl\/pathologie-van-metastatisch-adenocarcinoom\/","og_site_name":"Dermatly.com - El sitio de tu piel","article_modified_time":"2026-03-10T16:59:27+00:00","og_image":[{"width":294,"height":222,"url":"https:\/\/dermatly.com\/wp-content\/uploads\/2020\/11\/figure1metastaticadeno__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-2705924.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_misc":{"Geschatte leestijd":"2 minuten"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/dermatly.com\/patologia-del-adenocarcinoma-metastasico\/","url":"https:\/\/dermatly.com\/patologia-del-adenocarcinoma-metastasico\/","name":"Pathologie van metastatisch adenocarcinoom - Dermatly.com - De site voor uw huid","isPartOf":{"@id":"https:\/\/dermatly.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/dermatly.com\/patologia-del-adenocarcinoma-metastasico\/#primaryimage"},"image":{"@id":"https:\/\/dermatly.com\/patologia-del-adenocarcinoma-metastasico\/#primaryimage"},"thumbnailUrl":"https:\/\/dermatly.com\/wp-content\/uploads\/2020\/11\/figure1metastaticadeno__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-2705924.jpg","datePublished":"2020-11-21T05:55:13+00:00","dateModified":"2026-03-10T16:59:27+00:00","breadcrumb":{"@id":"https:\/\/dermatly.com\/patologia-del-adenocarcinoma-metastasico\/#breadcrumb"},"inLanguage":"nl-NL","potentialAction":[{"@type":"ReadAction","target":["https:\/\/dermatly.com\/patologia-del-adenocarcinoma-metastasico\/"]}]},{"@type":"ImageObject","inLanguage":"nl-NL","@id":"https:\/\/dermatly.com\/patologia-del-adenocarcinoma-metastasico\/#primaryimage","url":"https:\/\/dermatly.com\/wp-content\/uploads\/2020\/11\/figure1metastaticadeno__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-2705924.jpg","contentUrl":"https:\/\/dermatly.com\/wp-content\/uploads\/2020\/11\/figure1metastaticadeno__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-2705924.jpg","width":294,"height":222,"caption":"figure1metastaticadeno__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-2705924-8718964-jpg-6114455"},{"@type":"BreadcrumbList","@id":"https:\/\/dermatly.com\/patologia-del-adenocarcinoma-metastasico\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/dermatly.com\/"},{"@type":"ListItem","position":2,"name":"Glossary","item":"https:\/\/dermatly.com\/glossary\/"},{"@type":"ListItem","position":3,"name":"Patolog\u00eda del adenocarcinoma metast\u00e1sico"}]},{"@type":"WebSite","@id":"https:\/\/dermatly.com\/#website","url":"https:\/\/dermatly.com\/","name":"Dermatly.com - De website voor jouw huid","description":"Dermatologie en huidletsels","publisher":{"@id":"https:\/\/dermatly.com\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/dermatly.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"nl-NL"},{"@type":"Organization","@id":"https:\/\/dermatly.com\/#organization","name":"dermatly.com","url":"https:\/\/dermatly.com\/","logo":{"@type":"ImageObject","inLanguage":"nl-NL","@id":"https:\/\/dermatly.com\/#\/schema\/logo\/image\/","url":"https:\/\/dermatly.com\/wp-content\/uploads\/2020\/11\/dermatly-logo.png","contentUrl":"https:\/\/dermatly.com\/wp-content\/uploads\/2020\/11\/dermatly-logo.png","width":448,"height":110,"caption":"dermatly.com"},"image":{"@id":"https:\/\/dermatly.com\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/dermatly.com\/nl\/wp-json\/wp\/v2\/glossary\/14107","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dermatly.com\/nl\/wp-json\/wp\/v2\/glossary"}],"about":[{"href":"https:\/\/dermatly.com\/nl\/wp-json\/wp\/v2\/types\/glossary"}],"author":[{"embeddable":true,"href":"https:\/\/dermatly.com\/nl\/wp-json\/wp\/v2\/users\/1"}],"version-history":[{"count":2,"href":"https:\/\/dermatly.com\/nl\/wp-json\/wp\/v2\/glossary\/14107\/revisions"}],"predecessor-version":[{"id":26044,"href":"https:\/\/dermatly.com\/nl\/wp-json\/wp\/v2\/glossary\/14107\/revisions\/26044"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dermatly.com\/nl\/wp-json\/wp\/v2\/media\/14112"}],"wp:attachment":[{"href":"https:\/\/dermatly.com\/nl\/wp-json\/wp\/v2\/media?parent=14107"}],"wp:term":[{"taxonomy":"glossary-cat","embeddable":true,"href":"https:\/\/dermatly.com\/nl\/wp-json\/wp\/v2\/glossary-cat?post=14107"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}