{"id":8963,"date":"2020-11-15T18:24:14","date_gmt":"2020-11-15T18:24:14","guid":{"rendered":"https:\/\/dermatly.com\/patologia-de-la-epidermodisplasia-verruciforme\/"},"modified":"2026-03-10T16:05:36","modified_gmt":"2026-03-10T16:05:36","slug":"patologia-dell-epidermodisplasia-verruciforme-2","status":"publish","type":"glossary","link":"https:\/\/dermatly.com\/it\/patologia-de-la-epidermodisplasia-verruciforme\/","title":{"rendered":"Patologia dell'epidermodisplasia verruciforme"},"content":{"rendered":"<section class=\"textBlock\">\n<h1>Epidermodisplasia Verruciforme: Fundamentos, Histolog\u00eda y Diagn\u00f3stico Diferencial<\/h1>\n<p>La epidermodisplasia verruciforme (EV) constituye una <span class=\"term\" data-term-id=\"828\">genodermatosis<\/span> de herencia <span class=\"term\" data-term-id=\"828\">autos\u00f3mica<\/span> recesiva, generada por <span class=\"term\" data-term-id=\"871\">mutaciones<\/span> en los <span class=\"term\" data-term-id=\"775\">genes<\/span> <em>EVER1 \/ TMC6<\/em> o <em>EVER2 \/ TMC8<\/em>. Esta alteraci\u00f3n gen\u00e9tica resulta en una inmunodeficiencia innata espec\u00edfica contra determinados tipos del virus del papiloma humano (VPH). Adem\u00e1s, el EV puede manifestarse en pacientes afectados por el virus de la inmunodeficiencia humana (<span class=\"term\" data-term-id=\"127\">VIH<\/span>), o aquellos que padecen linfocitopenia de <span class=\"term\" data-term-id=\"631\">C\u00e9lulas T<\/span> CD8 o enfermedad de injerto contra hu\u00e9sped (<span class=\"term\" data-term-id=\"1313\">GVHD<\/span>).<\/p>\n<h2>Histopatolog\u00eda y Hallazgos Microsc\u00f3picos de la Epidermodisplasia Verruciforme<\/h2>\n<p><span class=\"term\" data-term-id=\"129\">Histopatol\u00f3gicamente<\/span>, las <span class=\"term\" data-term-id=\"2115\">lesiones<\/span> de la EV caracter\u00edsticamente presentan c\u00e9lulas agrandadas en la capa <span class=\"term\" data-term-id=\"2355\">granular<\/span> o espinosa. Estas c\u00e9lulas exhiben una hinchaz\u00f3n del <span class=\"term\" data-term-id=\"838\">citoplasma<\/span>, a menudo te\u00f1ida de gris azulado y muy particular, como se ilustra en la figura 1. Este aspecto es un reflejo directo de la <span class=\"term\" data-term-id=\"145\">infecci\u00f3n<\/span> por los tipos de VPH at\u00edpicos asociados a este trastorno. Es com\u00fan observar tambi\u00e9n gr\u00e1nulos de <span class=\"term\" data-term-id=\"520\">queratohialina<\/span> magnificados y la presencia de <span class=\"term\" data-term-id=\"866\">koilocitos<\/span>.<\/p>\n<p>Otras manifestaciones cut\u00e1neas observadas en el EV pueden adoptar la <span class=\"term\" data-term-id=\"187\">morfolog\u00eda<\/span> de verrugas planas o verrugas vulgares. Se postula que esta variaci\u00f3n morfol\u00f3gica se correlaciona con el subtipo espec\u00edfico de VPH que est\u00e1 causando la infecci\u00f3n.<\/p>\n<p>Es crucial notar que la <span class=\"term\" data-term-id=\"1118\">displasia<\/span> <span class=\"term\" data-term-id=\"1118\">queratinoc\u00edtica<\/span> y el <span class=\"term\" data-term-id=\"32\">carcinoma<\/span> <span class=\"term\" data-term-id=\"270\">escamoso<\/span> pueden desarrollarse y asociarse a las lesiones cut\u00e1neas inducidas por el VPH en pacientes con epidermodisplasia verruciforme.<\/p>\n<section class=\"textBlock imageLinkBlockTitle\">\n<h3 class=\"colour--primary\">Estudio de la Patolog\u00eda en Epidermodisplasia Verruciforme<\/h3>\n<\/section>\n<section class=\"imageLinkBlock\">\n<div class=\"flex\">\n<div class=\"imageLinkBlock__item__image\">\n                <img decoding=\"async\" src=\"https:\/\/dermatly.com\/wp-content\/uploads\/2020\/11\/epidermodysplasia-verruciformis-figure-1__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDBd.jpg\" alt=\"Microfotograf\u00eda mostrando la histopatolog\u00eda caracter\u00edstica de las lesiones de epidermodisplasia verruciforme con citoplasma p\u00e1lido y agrandado en la capa espinosa.\"><\/p>\n<p class=\"p-small\">Figura 1<\/p>\n<\/p><\/div>\n<\/p><\/div>\n<\/section>\n<div class=\"clearfix imageLinkBlock\"><\/div>\n<div id=\"square-placement-country-holder\" class=\"country-dependent advert\">\n<div class=\"box-placement square-placement\">\n<div class=\"advert__frame\">\n                <!-- \/340621630\/dermnet_mobile_afterfirstsection_300x250 --><\/p>\n<div style=\"display: none;\" id=\"hidden-div-gpt-ad-1484122037505-8\" class=\"[ js-hideable ]\"><\/div>\n<p>                <script>\n                    if (ads_screenwidth < 780 ) {\n                        var inline = document.createElement(\"div\");\n                        var ad = document.createElement(\"div\");\n\n                        ad.id = 'div-gpt-ad-1484122037505-8';\n                        ad.style.height=\"250px\";\n                        ad.style.width=\"300px;\";\n\n                        inline.appendChild(ad);\n                        inline.className = \"inline\";\n                        var placeholder = document.getElementById(\"hidden-div-gpt-ad-1484122037505-8\");\n                        placeholder.parentNode.replaceChild(inline, placeholder);\n                        (function () {\n                            googletag.cmd.push(function () {\n                                googletag.display('div-gpt-ad-1484122037505-8');\n                            });\n                        })();\n                    }\n                <\/script>\n            <\/div>\n<\/p><\/div>\n<\/p><\/div>\n<h2>Pruebas Diagn\u00f3sticas Especiales para la Epidermodisplasia Verruciforme<\/h2>\n<p>Para una identificaci\u00f3n precisa de los distintos subtipos de VPH asociados a la EV, se puede recurrir a la reacci\u00f3n en cadena de la polimerasa (<span class=\"term\" data-term-id=\"942\">PCR<\/span>). Hasta la fecha, se han documentado y aislado numerosos tipos virales, incluyendo VPH-3, 5, 8, 9, 10, 13, 14, 15, 17, 19 al 25, 28, 29, 36 al 38, 46, 47, 49, 50 y 59.<\/p>\n<h2>Diagn\u00f3stico Diferencial en la Patolog\u00eda de la Epidermodisplasia Verruciforme<\/h2>\n<p>El establecimiento del <span class=\"term\" data-term-id=\"813\">diagn\u00f3stico diferencial<\/span> debe considerar varias entidades que presentan cambios morfol\u00f3gicos similares a los observados en la EV. Ocasionalmente, focos de cambios EV pueden advertirse de forma incidental en piel con da\u00f1o act\u00ednico significativo, o como parte de un <span class=\"term\" data-term-id=\"800\">acantoma<\/span> d\u00e9rmico, lo que a veces se denomina \"acantoma-EV\".<\/p>\n<p>Respecto al carcinoma <span class=\"term\" data-term-id=\"863\">in situ<\/span> (Enfermedad de Bowen), es importante se\u00f1alar que el citoplasma de las <span class=\"term\" data-term-id=\"2272\">c\u00e9lulas escamosas<\/span> en un epitelio no inducido por VPH y que presenta <span class=\"term\" data-term-id=\"1829\">displasia<\/span> puede parecer p\u00e1lido o claro, replicando el aspecto visualizado en la Figura 1. Adem\u00e1s, las propias lesiones caracter\u00edsticas de la EV tienen el potencial subyacente de albergar <span class=\"term\" data-term-id=\"1828\">displasia<\/span> o progresar a carcinoma.<\/p>\n<\/section>\n","protected":false},"excerpt":{"rendered":"<p>Epidermodisplasia Verruciforme: Fundamentos, Histolog\u00eda y Diagn\u00f3stico Diferencial La epidermodisplasia verruciforme (EV) constituye una genodermatosis de herencia autos\u00f3mica recesiva, generada por mutaciones en los genes EVER1 \/ TMC6 o EVER2 \/ TMC8. Esta alteraci\u00f3n gen\u00e9tica resulta en una inmunodeficiencia innata espec\u00edfica contra determinados tipos del virus del papiloma humano (VPH). Adem\u00e1s, el EV puede manifestarse en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":8965,"parent":0,"template":"","glossary-cat":[],"class_list":["post-8963","glossary","type-glossary","status-publish","has-post-thumbnail","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.2 (Yoast SEO v27.1.1) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Patolog\u00eda de la epidermodisplasia verruciforme - Dermatly.com - El sitio de tu piel<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/dermatly.com\/it\/patologia-dell-epidermodisplasia-verruciforme-2\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Patolog\u00eda de la epidermodisplasia verruciforme\" \/>\n<meta property=\"og:description\" content=\"Epidermodisplasia Verruciforme: Fundamentos, Histolog\u00eda y Diagn\u00f3stico Diferencial La epidermodisplasia verruciforme (EV) constituye una genodermatosis de herencia autos\u00f3mica recesiva, generada por mutaciones en los genes EVER1 \/ TMC6 o EVER2 \/ TMC8. 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