{"id":7439,"date":"2020-11-14T07:00:47","date_gmt":"2020-11-14T07:00:47","guid":{"rendered":"https:\/\/dermatly.com\/mosaicismo-cutaneo\/"},"modified":"2026-03-10T16:12:04","modified_gmt":"2026-03-10T16:12:04","slug":"mosaicismo-cutaneo","status":"publish","type":"glossary","link":"https:\/\/dermatly.com\/it\/mosaicismo-cutaneo\/","title":{"rendered":"Mosaico cutaneo"},"content":{"rendered":"<section class=\"textBlock\">\n<h1>Definici\u00f3n y Clasificaci\u00f3n del Mosaicismo Cut\u00e1neo<\/h1>\n<p>El mosaicismo se define como la presencia de dos o m\u00e1s poblaciones celulares gen\u00e9ticamente distintas coexistiendo dentro de la piel de un individuo. Estas dos l\u00edneas celulares se originan muy temprano en el desarrollo embrionario.<\/p>\n<p>Varias afecciones gen\u00e9ticas dermatol\u00f3gicas manifiestan patrones asociados al <dfn class=\"term\" data-term-id=\"47\">cut\u00e1neo<\/dfn> mosaicismo.<\/p>\n<p>Existen dos categor\u00edas gen\u00e9ticas principales:<\/p>\n<ul>\n<li>Mosaicismo funcional, el cual resulta de la inactivaci\u00f3n del <span class=\"term\" data-term-id=\"1271\">cromosoma<\/span> X.<\/li>\n<li>Mosaicismo gen\u00f3mico, que se deriva de una <span class=\"term\" data-term-id=\"828\">autos\u00f3mico<\/span> <span class=\"term\" data-term-id=\"870\">mutaci\u00f3n<\/span> (una alteraci\u00f3n en uno de los 46 cromosomas no sexuales, <span class=\"term\" data-term-id=\"1272\">cromosomas<\/span>).<\/li>\n<\/ul>\n<h2>Patrones Clasificados del Mosaicismo Cut\u00e1neo<\/h2>\n<p>Se han identificado y documentado cinco patrones distintos de distribuci\u00f3n del mosaicismo en la piel.[1]<\/p>\n<table class=\"borders\">\n<tbody>\n<tr>\n<th>Tipo<\/th>\n<th>Patr\u00f3n Observado<\/th>\n<th>Ejemplo de Condici\u00f3n Asociada<\/th>\n<\/tr>\n<tr>\n<td>Tipo 1a<\/td>\n<td><span class=\"term\" data-term-id=\"25\">L\u00edneas de Blaschko<\/span>, bandas estrechas<\/td>\n<td>Incontinentia pigmenti<\/td>\n<\/tr>\n<tr>\n<td>Tipo 1b<\/td>\n<td>L\u00edneas de Blaschko, bandas anchas<\/td>\n<td><span class=\"term\" data-term-id=\"350\">s\u00edndrome<\/span> de McCune-Albright<\/td>\n<\/tr>\n<tr>\n<td>Tipo 2<\/td>\n<td>Patr\u00f3n de tablero de ajedrez<\/td>\n<td><span class=\"term\" data-term-id=\"353\">nevo<\/span> de Becker \/ <span class=\"term\" data-term-id=\"753\">malformaci\u00f3n<\/span> <span class=\"term\" data-term-id=\"1631\">vascular<\/span> (Mancha en Vino de Oporto)<\/td>\n<\/tr>\n<tr>\n<td>Tipo 3<\/td>\n<td>Patr\u00f3n filoide (con forma de hoja)<\/td>\n<td>Trisom\u00eda 13 en mosaico<\/td>\n<\/tr>\n<tr>\n<td>Tipo 4<\/td>\n<td>Grandes parches sin separaci\u00f3n en la <span class=\"term\" data-term-id=\"1543\">l\u00ednea media<\/span><\/td>\n<td>Nevus <span class=\"term\" data-term-id=\"785\">melanoc\u00edtico<\/span> <span class=\"term\" data-term-id=\"1036\">cong\u00e9nito<\/span> grande<\/td>\n<\/tr>\n<tr>\n<td>Tipo 5<\/td>\n<td>Lateralizaci\u00f3n<\/td>\n<td>S\u00edndrome de CLOVES (NI\u00d1O)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Ciertas afecciones, como el vitiligo <span class=\"term\" data-term-id=\"619\">segmentario<\/span>, pueden manifestarse a trav\u00e9s de m\u00faltiples patrones de mosaico. Los afectados suelen presentar \u00abmarcas de nacimiento\u00bb caracter\u00edsticas que se atribuyen a <span class=\"term\" data-term-id=\"871\">mutaciones<\/span> som\u00e1ticas en <span class=\"term\" data-term-id=\"775\">genes<\/span> conocidos o a\u00fan no identificados.<\/p>\n<p>Un ejemplo ilustrativo es el s\u00edndrome de Proteus, en el que un <span class=\"term\" data-term-id=\"774\">gen<\/span> AKT1 an\u00f3malo presente en algunas c\u00e9lulas desencadena la activaci\u00f3n de una <span class=\"term\" data-term-id=\"2224\">prote\u00edna<\/span> que promueve el crecimiento. Estas condiciones causan diversas formas de sobrecrecimiento y <span class=\"term\" data-term-id=\"354\">nevi<\/span>, los cuales pueden <span class=\"term\" data-term-id=\"2221\">progresar<\/span> a lo largo de la vida del paciente.<\/p>\n<div id=\"square-placement-country-holder\" class=\"country-dependent advert\">\n<div class=\"box-placement square-placement\">\n<div class=\"advert__frame\">\n                <!-- \/340621630\/dermnet_mobile_afterfirstsection_300x250 --><\/p>\n<div style=\"display: none;\" id=\"hidden-div-gpt-ad-1484122037505-8\" class=\"[ js-hideable ]\"><\/div>\n<p>                <script>\n                    if (ads_screenwidth < 780 ) {\n                        var inline = document.createElement(\"div\");\n                        var ad = document.createElement(\"div\");\n\n                        ad.id = 'div-gpt-ad-1484122037505-8';\n                        ad.style.height=\"250px\";\n                        ad.style.width=\"300px;\";\n\n                        inline.appendChild(ad);\n                        inline.className = \"inline\";\n                        var placeholder = document.getElementById(\"hidden-div-gpt-ad-1484122037505-8\");\n                        placeholder.parentNode.replaceChild(inline, placeholder);\n                        (function () {\n                            googletag.cmd.push(function () {\n                                googletag.display('div-gpt-ad-1484122037505-8');\n                            });\n                        })();\n                    }\n                <\/script>\n            <\/div>\n<\/p><\/div>\n<\/p><\/div>\n<h2>Relaci\u00f3n entre Blaschko y la Distribuci\u00f3n del Mosaicismo Cut\u00e1neo<\/h2>\n<p>Las <span class=\"term\" data-term-id=\"2115\">lesiones<\/span> cut\u00e1neas que siguen las <span class=\"term\" data-term-id=\"25\">l\u00edneas de Blaschko<\/span> representan una <span class=\"term\" data-term-id=\"2131\">manifestaci\u00f3n<\/span> espec\u00edfica del mosaicismo d\u00e9rmico. Estas l\u00edneas demarcan las v\u00edas de divisi\u00f3n celular que las dos poblaciones celulares embrionarias siguieron al formar el tejido de la piel.<\/p>\n<p>Es importante notar que el mosaicismo cut\u00e1neo no siempre respeta estrictamente las l\u00edneas de Blaschko. Esta discrepancia a menudo se correlaciona con el momento exacto en que surge la alteraci\u00f3n gen\u00e9tica durante las fases tempranas del <span class=\"term\" data-term-id=\"2341\">desarrollo<\/span>.<\/p>\n<h2>Investigaci\u00f3n y Diagn\u00f3stico en Casos de Mosaicismo Cut\u00e1neo<\/h2>\n<p>Los pacientes diagnosticados con trastornos en mosaico pueden ser referidos a un especialista en gen\u00e9tica para una evaluaci\u00f3n exhaustiva. El an\u00e1lisis del tejido afectado es crucial para identificar las <span class=\"term\" data-term-id=\"1422\">som\u00e1tico<\/span> mutaciones responsables de la patolog\u00eda cut\u00e1nea. El m\u00e9todo diagn\u00f3stico avanzado preferido para esta b\u00fasqueda suele ser la secuenciaci\u00f3n completa del exoma.<\/p>\n<p>Comprender el origen gen\u00e9tico preciso es fundamental para el manejo a largo plazo de estas complejas condiciones dermatol\u00f3gicas.<\/p>\n<\/section>\n","protected":false},"excerpt":{"rendered":"<p>Definici\u00f3n y Clasificaci\u00f3n del Mosaicismo Cut\u00e1neo El mosaicismo se define como la presencia de dos o m\u00e1s poblaciones celulares gen\u00e9ticamente distintas coexistiendo dentro de la piel de un individuo. Estas dos l\u00edneas celulares se originan muy temprano en el desarrollo embrionario. Varias afecciones gen\u00e9ticas dermatol\u00f3gicas manifiestan patrones asociados al cut\u00e1neo mosaicismo. Existen dos categor\u00edas gen\u00e9ticas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"template":"","glossary-cat":[],"class_list":["post-7439","glossary","type-glossary","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.2 (Yoast SEO v27.1.1) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Mosaicismo cut\u00e1neo - Dermatly.com - El sitio de tu piel<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/dermatly.com\/it\/mosaicismo-cutaneo\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Mosaicismo cut\u00e1neo\" \/>\n<meta property=\"og:description\" content=\"Definici\u00f3n y Clasificaci\u00f3n del Mosaicismo Cut\u00e1neo El mosaicismo se define como la presencia de dos o m\u00e1s poblaciones celulares gen\u00e9ticamente distintas coexistiendo dentro de la piel de un individuo. Estas dos l\u00edneas celulares se originan muy temprano en el desarrollo embrionario. Varias afecciones gen\u00e9ticas dermatol\u00f3gicas manifiestan patrones asociados al cut\u00e1neo mosaicismo. 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Estas dos l\u00edneas celulares se originan muy temprano en el desarrollo embrionario. Varias afecciones gen\u00e9ticas dermatol\u00f3gicas manifiestan patrones asociados al cut\u00e1neo mosaicismo. 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