{"id":7189,"date":"2020-11-14T04:19:29","date_gmt":"2020-11-14T04:19:29","guid":{"rendered":"https:\/\/dermatly.com\/reacciones-adversas-cutaneas-a-los-inhibidores-de-la-calcineurina-2\/"},"modified":"2026-03-10T16:08:06","modified_gmt":"2026-03-10T16:08:06","slug":"reazioni-avverse-cutanee-agli-inibitori-della-calcineurina-2","status":"publish","type":"glossary","link":"https:\/\/dermatly.com\/it\/reacciones-adversas-cutaneas-a-los-inhibidores-de-la-calcineurina-2\/","title":{"rendered":"Reazioni avverse cutanee agli inibitori della calcineurina"},"content":{"rendered":"<section class=\"textBlock\">\n<h1>Inhibidores de la Calcineurina: Mecanismo y Aplicaciones T\u00f3picas<\/h1>\n<p>Los inhibidores de la calcineurina son una clase de f\u00e1rmacos que ejercen su acci\u00f3n al suprimir la actividad de la calcineurina, una<br \/>\n        <span class=\"term\" data-term-id=\"1525\">enzima<\/span> calcio<span class=\"term\" data-term-id=\"1179\">dependiente<\/span><br \/>\n        <span class=\"term\" data-term-id=\"2450\">prote\u00edna<\/span> <span class=\"term\" data-term-id=\"2224\">fosfatasa<\/span>. Esta inhibici\u00f3n previene la activaci\u00f3n de los <span class=\"term\" data-term-id=\"419\">T <span class=\"term\" data-term-id=\"421\">linfocitos<\/span><\/span> mediante la regulaci\u00f3n positiva de <span class=\"term\" data-term-id=\"915\">interleucina<\/span>-2 y <span class=\"term\" data-term-id=\"434\">citocinas<\/span> relacionadas, logrando as\u00ed un efecto inmunosupresor [1].<\/p>\n<ul>\n<li>Los principales inhibidores de la calcineurina administrados por v\u00eda oral son: ciclosporina y tacrolimus.<\/li>\n<li>Actualmente, los inhibidores de calcineurina disponibles en formulaciones t\u00f3picas incluyen tacrolimus (en presentaciones de <span class=\"term\" data-term-id=\"1122\">ung\u00fcento<\/span> al 0.03% o 0.1%) y pimecrolimus (en <span class=\"term\" data-term-id=\"1121\">crema<\/span> al 1%) [2,3].<\/li>\n<\/ul>\n<h2>Usos de los Inhibidores T\u00f3picos de la Calcineurina en Dermatolog\u00eda<\/h2>\n<p>Las formulaciones t\u00f3picas de tacrolimus y pimecrolimus est\u00e1n espec\u00edficamente aprobadas para el tratamiento de la <span class=\"term\" data-term-id=\"53\">dermatitis<\/span> <span class=\"term\" data-term-id=\"922\">at\u00f3pica<\/span>.<\/p>\n<p>No obstante, su utilidad se extiende frecuentemente en la pr\u00e1ctica <span class=\"term\" data-term-id=\"55\">dermatol\u00f3gica<\/span> para indicaciones \u00abfuera de etiqueta\u00bb (off-label), tales como:<\/p>\n<ul>\n<li>Psoriasis facial, de <span class=\"term\" data-term-id=\"497\">flexuras<\/span> y genital.<\/li>\n<li><span class=\"term\" data-term-id=\"378\">Dermatitis<\/span> <span class=\"term\" data-term-id=\"319\">seborreica<\/span>.<\/li>\n<li>Dermatitis cr\u00f3nica de la mano.<\/li>\n<li>Dermatitis de contacto.<\/li>\n<li>Vitiligo.<\/li>\n<li>Morfea.<\/li>\n<li>Lupus eritematoso <span class=\"term\" data-term-id=\"47\">cut\u00e1neo<\/span>.<\/li>\n<li>Liquen plano oral y <span class=\"term\" data-term-id=\"537\">erosivo<\/span> vulvar [2,4].<\/li>\n<\/ul>\n<p>Una ventaja significativa de los inhibidores t\u00f3picos de la calcineurina radica en que evitan muchos de los efectos adversos comunes asociados con los <span class=\"term\" data-term-id=\"2010\">corticosteroides<\/span> t\u00f3picos. Estos medicamentos t\u00f3picos no provocan estr\u00edas, <span class=\"term\" data-term-id=\"18\">atrofia<\/span> cut\u00e1nea, el riesgo de <span class=\"term\" data-term-id=\"975\">glaucoma<\/span>, los brotes por rebote, ni la absorci\u00f3n <span class=\"term\" data-term-id=\"380\">sist\u00e9mica<\/span>, eliminando tambi\u00e9n el potencial de supresi\u00f3n del eje <span class=\"term\" data-term-id=\"2206\">hipotal\u00e1mico<\/span>\u2013<span class=\"term\" data-term-id=\"1358\">pituitaria<\/span>\u2013suprarrenal (HPA).<\/p>\n<section class=\"textBlock imageLinkBlockTitle\">\n<h3 class=\"colour--primary\">Indicaciones Cl\u00ednicas Ilustradas de los Inhibidores T\u00f3picos de la Calcineurina<\/h3>\n<\/section>\n<section class=\"imageLinkBlock\">\n<div class=\"flex\">\n<div class=\"imageLinkBlock__item__image\">\n<figure>\n                    <img decoding=\"async\" src=\"https:\/\/dermatly.com\/wp-content\/uploads\/2020\/11\/atopic15__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd.jpg\" alt=\"Caso de dermatitis at\u00f3pica afectando el p\u00e1rpado\"><br \/>\n                <\/figure>\n<\/p><\/div>\n<p class=\"p-small\">Dermatitis at\u00f3pica del p\u00e1rpado<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<figure>\n                    <img decoding=\"async\" src=\"https:\/\/dermatly.com\/wp-content\/uploads\/2020\/11\/flexural-psoriasis-alt2__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsInkiLDEwXQ.JPG\" alt=\"Ejemplo de psoriasis en una zona de flexura, como la axila\"><br \/>\n                <\/figure>\n<\/p><\/div>\n<p class=\"p-small\">Psoriasis de axila<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<figure>\n                    <img decoding=\"async\" src=\"https:\/\/dermatly.com\/wp-content\/uploads\/2020\/11\/vitiligo-19-v2__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd.JPG\" alt=\"Vitiligo mostrando despigmentaci\u00f3n alrededor de los labios y la boca\"><br \/>\n                <\/figure>\n<\/p><\/div>\n<p class=\"p-small\">Vitiligo que afecta los labios y la piel perioral.<\/p>\n<\/p><\/div>\n<\/section>\n<div class=\"clearfix imageLinkBlock\"><\/div>\n<div id=\"square-placement-country-holder\" class=\"country-dependent advert\">\n<div class=\"box-placement square-placement\">\n<div class=\"advert__frame\">\n                        <!-- \/340621630\/dermnet_mobile_afterfirstsection_300x250 --><\/p>\n<div style=\"display: none;\" id=\"hidden-div-gpt-ad-1484122037505-8\" class=\"[ js-hideable ]\"><\/div>\n<p><script>\n    if (ads_screenwidth\n<\/section>\n<p><script>\n    if (window.innerWidth < 780) {\n        var inline = document.createElement(\"div\");\n        var ad = document.createElement(\"div\");\n\n        ad.id = 'div-gpt-ad-1484122037505-8';\n        ad.style.height=\"250px\";\n        ad.style.width=\"300px;\";\n\n        inline.appendChild(ad);\n        inline.className = \"inline\";\n        var placeholder = document.getElementById(\"hidden-div-gpt-ad-1484122037505-8\");\n        placeholder.parentNode.replaceChild(inline, placeholder);\n        (function () {\n            googletag.cmd.push(function () {\n                googletag.display('div-gpt-ad-1484122037505-8');\n            });\n        })();\n    }\n<\/script>\n<\/div>\n<\/div>\n<h1>Usos y Efectos Secundarios de los Inhibidores de la Calcineurina<\/h1>\n<h2>Aplicaciones Cl\u00ednicas de los Inhibidores de la Calcineurina Orales<\/h2>\n<p>Los inhibidores de la calcineurina administrados por v\u00eda oral son fundamentales para inducir la inmunosupresi\u00f3n despu\u00e9s de un <span class=\"term\" data-term-id=\"1128\">trasplante<\/span> de \u00d3rgano <span class=\"term\" data-term-id=\"1793\">s\u00f3lido<\/span>. Adem\u00e1s, la ciclosporina sist\u00e9mica y el tacrolimus ocasionalmente se emplean en el tratamiento de enfermedades inmunomediadas, como la psoriasis y la dermatitis at\u00f3pica. No obstante, su uso en estas afecciones se reserva principalmente para pacientes que no han obtenido resultados satisfactorios con terapias convencionales [3].<\/p>\n<h2>Efectos Secundarios Dermatol\u00f3gicos de los Inhibidores T\u00f3picos de la Calcineurina<\/h2>\n<p>El evento adverso m\u00e1s frecuentemente reportado al utilizar inhibidores t\u00f3picos de la calcineurina es la irritaci\u00f3n local, manifestada frecuentemente como <span class=\"term\" data-term-id=\"245\">prurito<\/span> y <span class=\"term\" data-term-id=\"90\">eritema<\/span> justo en el \u00e1rea de aplicaci\u00f3n. Afortunadamente, esta reacci\u00f3n suele ser <span class=\"term\" data-term-id=\"2294\">transitoria<\/span>, disminuyendo su intensidad progresivamente, generalmente dentro del primer mes de uso.<\/p>\n<p>Otros efectos adversos cut\u00e1neos que pueden presentarse incluyen:<\/p>\n<ul>\n<li>Dermatitis al\u00e9rgica de contacto.<\/li>\n<li>Desarrollo de foliculitis.<\/li>\n<li>Reactivaci\u00f3n de <span class=\"term\" data-term-id=\"145\">infecciones<\/span>, espec\u00edficamente herpes <span class=\"term\" data-term-id=\"2354\">simplex<\/span> y verrugas virales.<\/li>\n<li>Exacerbaci\u00f3n del enrojecimiento facial tras la <span class=\"term\" data-term-id=\"406\">ingesti\u00f3n<\/span> de alcohol.<\/li>\n<li>Aparici\u00f3n de una dermatitis con caracter\u00edsticas similares a la ros\u00e1cea.<\/li>\n<li>Acn\u00e9 localizado en la zona facial.<\/li>\n<li>Desarrollo de molusco contagioso.<\/li>\n<li>Diagn\u00f3stico de ti\u00f1a incognita.<\/li>\n<\/ul>\n<p>Actualmente, no existe evidencia concluyente que respalde la preocupaci\u00f3n te\u00f3rica sobre un posible aumento del riesgo de <span class=\"term\" data-term-id=\"1742\">malignidad<\/span> cut\u00e1nea \u2014como el <span class=\"term\" data-term-id=\"831\">carcinoma<\/span> de c\u00e9lulas <span class=\"term\" data-term-id=\"32\">basales<\/span>, el carcinoma de c\u00e9lulas <span class=\"term\" data-term-id=\"270\">escamosas<\/span>, el <span class=\"term\" data-term-id=\"1670\">melanoma<\/span> y el <span class=\"term\" data-term-id=\"976\">linfoma<\/span> cut\u00e1neo\u2014 asociado al uso de estos inhibidores t\u00f3picos. La informaci\u00f3n que sugiere este riesgo proviene de datos obtenidos en estudios con animales, reportes de casos aislados en un n\u00famero reducido de pacientes y del mecanismo de acci\u00f3n conocido de los f\u00e1rmacos [2,4,5].<\/p>\n<section class=\"textBlock imageLinkBlockTitle\">\n<h5 class=\"colour--primary\">Efectos adversos potenciales de los inhibidores t\u00f3picos de la calcineurina<\/h5>\n<\/section>\n<section class=\"imageLinkBlock\">\n<div class=\"flex\">\n<div class=\"imageLinkBlock__item__image\">\n            <img decoding=\"async\" src=\"https:\/\/dermatly.com\/wp-content\/uploads\/2020\/11\/herpes-simplex-labialis-03__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd.JPG\" alt=\"Imagen ilustrativa de un brote de herpes labial simple\">\n        <\/div>\n<p class=\"p-small\">Herpes labial simple<\/p>\n<div class=\"imageLinkBlock__item__image\">\n            <img decoding=\"async\" src=\"https:\/\/dermatly.com\/wp-content\/uploads\/2020\/11\/3429__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd.jpg\" alt=\"Imagen ilustrativa de dermatitis perioral\">\n        <\/div>\n<p class=\"p-small\">Dermatitis perioral<\/p>\n<div class=\"imageLinkBlock__item__image\">\n            <img decoding=\"async\" src=\"https:\/\/dermatly.com\/wp-content\/uploads\/2020\/11\/tintin2__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd.jpg\" alt=\"Imagen ilustrativa de ti\u00f1a de inc\u00f3gnito\">\n        <\/div>\n<p class=\"p-small\">Ti\u00f1a de inc\u00f3gnito<\/p>\n<\/p><\/div>\n<\/section>\n<div class=\"clearfix imageLinkBlock\"><\/div>\n<h2>Efectos Secundarios Mucocut\u00e1neos de los Inhibidores de la Calcineurina Orales<\/h2>\n<p>Los efectos adversos asociados al uso de tacrolimus y ciclosporina por v\u00eda oral son generalmente similares entre s\u00ed. Estos incluyen una serie de manifestaciones adversas:<\/p>\n<ul>\n<li><span class=\"term\" data-term-id=\"344\">Hiperplasia<\/span> <span class=\"term\" data-term-id=\"136\">gingival<\/span>.<\/li>\n<li><span class=\"term\" data-term-id=\"1809\">Hipertricosis<\/span>.<\/li>\n<\/ul>\n<p>```html<\/p>\n<ul>\n<li>Inducido por medicamentos alopecia (Las altas dosis de tacrolimus y ciclosporina se asocian con un mayor riesgo de p\u00e9rdida de cabello)<\/li>\n<li>Prurito inducido por f\u00e1rmacos<\/li>\n<li>Acn\u00e9 inducido por medicamentos<\/li>\n<li>Enrojecimiento<\/li>\n<li>Hiperhidrosis generalizada<\/li>\n<li>Un mayor riesgo de carcinoma de c\u00e9lulas escamosas de la piel [1,3].\n    <\/li>\n<\/ul>\n<section class=\"textBlock imageLinkBlockTitle\">\n<h2 class=\"colour--primary\">Efectos adversos de los inhibidores de la calcineurina orales<\/h2>\n<\/section>\n<section class=\"imageLinkBlock\">\n<div class=\"flex\">\n<div class=\"imageLinkBlock__item__image\">\n            <img decoding=\"async\" src=\"https:\/\/dermatly.com\/wp-content\/uploads\/2020\/11\/csa-gums__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDIwXQ.jpg\" alt=\"Hipertrofia de las enc\u00edas causada por la ciclosporina\">\n        <\/div>\n<p class=\"p-small\">Hipertrofia de las enc\u00edas por ciclosporina<\/p>\n<div class=\"imageLinkBlock__item__image\">\n            <img decoding=\"async\" src=\"https:\/\/dermatly.com\/wp-content\/uploads\/2020\/11\/hypertrichosis-ciclosporin-06__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd.JPG\" alt=\"Hipertricosis causada por la ciclosporina\">\n        <\/div>\n<p class=\"p-small\">Hipertricosis por ciclosporina<\/p>\n<div class=\"imageLinkBlock__item__image\">\n            <img decoding=\"async\" src=\"https:\/\/dermatly.com\/wp-content\/uploads\/2020\/11\/squamous-cell-carcinoma-dorsal-hand__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd.JPG\" alt=\"Carcinoma cut\u00e1neo de c\u00e9lulas escamosas en la mano\">\n        <\/div>\n<p class=\"p-small\">Un carcinoma de c\u00e9lulas escamosas de la mano dorsal moderadamente bien diferenciado y confirmado histol\u00f3gicamente<\/p>\n<\/p><\/div>\n<\/section>\n<div class=\"clearfix imageLinkBlock\"><\/div>\n<div id=\"square-placement-country-holder\" class=\"country-dependent advert\">\n<div class=\"box-placement square-placement\">\n<div class=\"advert__frame\">\n            <!-- \/340621630\/dermnet_mobile_after4sections_300x250' --><\/p>\n<div style=\"display: none;\" id=\"hidden-div-gpt-ad-1484122037505-9\" class=\"[ js-hideable ]\"><\/div>\n<p>            <script>\n                if (ads_screenwidth < 780 ) {\n                    var inline = document.createElement(\"div\");\n                    var ad = document.createElement(\"div\");\n\n                    ad.id = 'div-gpt-ad-1484122037505-9';\n                    ad.style.height=\"250px\";\n                    ad.style.width=\"300px;\";\n\n                    inline.appendChild(ad);\n                    inline.className = \"inline\";\n                    var placeholder = document.getElementById(\"hidden-div-gpt-ad-1484122037505-9\");\n                    placeholder.parentNode.replaceChild(inline, placeholder);\n                    (function () {\n                        googletag.cmd.push(function () {\n                            googletag.display('div-gpt-ad-1484122037505-9');\n                        });\n                    })();\n                }\n            <\/script>\n        <\/div>\n<\/p><\/div>\n<\/div>\n<h2>\u00bfCu\u00e1les son los efectos secundarios no cut\u00e1neos de los inhibidores de la calcineurina?<\/h2>\n<p>Los inhibidores de la calcineurina pueden provocar efectos secundarios que afectan a otras partes del cuerpo adem\u00e1s de la piel.<\/p>\n<h2>Inhibidores de calcineurina orales: Efectos Secundarios Sist\u00e9micos<\/h2>\n<p>La administraci\u00f3n oral de inhibidores de la calcineurina puede desencadenar una variedad de efectos adversos significativos:<\/p>\n<ul>\n<li>Nefrotoxicidad (considerado el efecto secundario m\u00e1s frecuente)<\/li>\n<li>Hipertensi\u00f3n<\/li>\n<li>Neurotoxicidad (manifest\u00e1ndose como temblores, cefaleas intensas, anormalidades neurol\u00f3gicas, convulsiones, encefalopat\u00eda e incluso coma)<\/li>\n<li>Anormalidades metab\u00f3licas (intolerancia a la glucosa, hiperlipidemia, hiperuricemia, hiperpotasemia, hipomagnesemia, disfunci\u00f3n hep\u00e1tica con ictericia)<\/li>\n<li>Infecciones (por agentes bacterianos, virales y f\u00fangicos)<\/li>\n<li>Mayor riesgo de neoplasia (trastornos linfoproliferativos benignos y malignos, incluyendo linfoma)<\/li>\n<li>Efectos secundarios gastrointestinales (n\u00e1useas, v\u00f3mitos, diarrea y malestar abdominal) [1,3].\n    <\/li>\n<\/ul>\n<h2>Inhibidores t\u00f3picos de la calcineurina<\/h2>\n<p>Los inhibidores de calcineurina aplicados t\u00f3picamente generalmente no inducen efectos secundarios sist\u00e9micos significativos, dado que se absorbe menos del 0,1% de la dosis aplicada, salvo en casos de barreras cut\u00e1neas gravemente comprometidas. Estudios epidemiol\u00f3gicos amplios no han establecido una correlaci\u00f3n entre el uso de inhibidores t\u00f3picos de la calcineurina y un riesgo incrementado de linfoma u otras malignidades; no obstante, una revisi\u00f3n Cochrane advirti\u00f3 que estas conclusiones pueden estar limitadas por la escasez de datos concluyentes [6, 7].<\/p>\n<p>```<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Inhibidores de la Calcineurina: Mecanismo y Aplicaciones T\u00f3picas Los inhibidores de la calcineurina son una clase de f\u00e1rmacos que ejercen su acci\u00f3n al suprimir la actividad de la calcineurina, una enzima calciodependiente prote\u00edna fosfatasa. Esta inhibici\u00f3n previene la activaci\u00f3n de los T linfocitos mediante la regulaci\u00f3n positiva de interleucina-2 y citocinas relacionadas, logrando as\u00ed un [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":7188,"parent":0,"template":"","glossary-cat":[],"class_list":["post-7189","glossary","type-glossary","status-publish","has-post-thumbnail","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.2 (Yoast SEO v27.1.1) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Reacciones adversas cut\u00e1neas a los inhibidores de la calcineurina - Dermatly.com - El sitio de tu piel<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/dermatly.com\/it\/reazioni-avverse-cutanee-agli-inibitori-della-calcineurina-2\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Reacciones adversas cut\u00e1neas a los inhibidores de la calcineurina\" \/>\n<meta property=\"og:description\" content=\"Inhibidores de la Calcineurina: Mecanismo y Aplicaciones T\u00f3picas Los inhibidores de la calcineurina son una clase de f\u00e1rmacos que ejercen su acci\u00f3n al suprimir la actividad de la calcineurina, una enzima calciodependiente prote\u00edna fosfatasa. Esta inhibici\u00f3n previene la activaci\u00f3n de los T linfocitos mediante la regulaci\u00f3n positiva de interleucina-2 y citocinas relacionadas, logrando as\u00ed un [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/dermatly.com\/it\/reazioni-avverse-cutanee-agli-inibitori-della-calcineurina-2\/\" \/>\n<meta property=\"og:site_name\" content=\"Dermatly.com - El sitio de tu piel\" \/>\n<meta property=\"article:modified_time\" content=\"2026-03-10T16:08:06+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/dermatly.com\/wp-content\/uploads\/2020\/11\/atopic15__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-4514540.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"294\" \/>\n\t<meta property=\"og:image:height\" content=\"222\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Tempo di lettura stimato\" \/>\n\t<meta name=\"twitter:data1\" content=\"5 minuti\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/dermatly.com\/reacciones-adversas-cutaneas-a-los-inhibidores-de-la-calcineurina-2\/\",\"url\":\"https:\/\/dermatly.com\/reacciones-adversas-cutaneas-a-los-inhibidores-de-la-calcineurina-2\/\",\"name\":\"Reacciones adversas cut\u00e1neas a los inhibidores de la calcineurina - 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