{"id":7123,"date":"2020-11-14T02:57:21","date_gmt":"2020-11-14T02:57:21","guid":{"rendered":"https:\/\/dermatly.com\/patologia-metastasica-de-la-enfermedad-de-crohn\/"},"modified":"2026-03-10T16:06:18","modified_gmt":"2026-03-10T16:06:18","slug":"patologia-metastatica-del-morbo-di-crohn","status":"publish","type":"glossary","link":"https:\/\/dermatly.com\/it\/patologia-metastasica-de-la-enfermedad-de-crohn\/","title":{"rendered":"Patologia metastatica del morbo di Crohn"},"content":{"rendered":"
\n

Regole Assolute della Malattia di Crohn Metastatica e la sua Patologia Cutanea<\/h1>\n

I pazienti affetti da malattia di Crohn sono a rischio di sviluppare **lesioni** cutanee sterili e granulomatose<\/span> al di fuori del tratto gastrointestinale. Questa manifestazione \u00e8 denominata Malattia di Crohn Metastatica<\/span> (MCD). Quando colpisce specificamente la pelle, \u00e8 conosciuta come Malattia di Crohn Cutanea<\/span>. Clinicamente, la MCD si presenta come una manifestazione solitaria o multipla di noduli<\/span>, placche<\/span>, ulcere<\/span>, lesioni lichenoidi<\/span>, o papule<\/span> in distribuzione perifollicolare<\/span> di colore violaceo<\/span>.<\/p>\n

Istologia della Malattia di Crohn Metastatica<\/h2>\n

La Malattia di Crohn Metastatica<\/span> \u00e8 caratterizzata istologicamente da un infiltrato<\/span> granulomatoso nel derma derma<\/span>, composto principalmente da istociti<\/span> epitelioidi (visualizzato nelle figure da 1 a 5). Questo infiltrato \u00e8 solitamente accompagnato da una reazione prevalentemente linfocitaria<\/span>, sebbene occasionalmente possa essere denso di eosinofili<\/span>. I granulomi<\/span> hanno la capacit\u00e0 di invadere l' epidermide<\/span> epidermide (Figura 1). Inoltre, \u00e8 possibile osservare un edema massivo (figura 2) e l' ulcerazione<\/span> ulcerazione dell'epidermide sovrastante costituisce una caratteristica frequente (figura 4).<\/p>\n

In alcuni casi di Malattia di Crohn Metastatica<\/span>, si possono identificare anche segni di vasculite<\/span> granulomatosa e necrosi<\/span>.<\/p>\n

\n

Patologia metastatica del morbo di Crohn<\/h3>\n<\/section>\n
\n
\n
\n \"Microfotografia<\/p>\n

Figura 1<\/p>\n<\/p><\/div>\n

\n \"Microfotografia<\/p>\n

Figura 2<\/p>\n<\/p><\/div>\n

\n \"Microfotografia<\/p>\n

figura 3<\/p>\n<\/p><\/div>\n

\n \"Microfotografia<\/p>\n

Figura 4<\/p>\n<\/p><\/div>\n

\n \"Microfotografia<\/p>\n

Figura 5<\/p>\n<\/p><\/div>\n<\/p><\/div>\n<\/section>\n

<\/div>\n

Diagnosi Differenziale della Malattia di Crohn Metastatica<\/h2>\n

Stabilire la **diagnosi differenziale** della malattia di Crohn metastatica<\/span> \u00e8 cruciale, poich\u00e9 diverse condizioni possono imitare i suoi reperti istologici.<\/p>\n

Sarcoidosi:<\/strong> Differenziarla pu\u00f2 essere complesso senza un'adeguata correlazione clinica. I granulomi<\/span> osservati nella malattia di Crohn sono tipicamente meno ben definiti<\/span> (come si vede nella figura 5) rispetto alla sarcoidosi. Inoltre, l'ulcerazione e la densit\u00e0 di eosinofili sono reperti meno comuni nella sarcoidosi.<\/p>\n

Infezione Micobatterica:<\/strong> \u00c8 imperativo escludere la presenza di infezione da micobatteri. Ci\u00f2 richiede l'esecuzione di colorazioni speciali e il relativo esame colturale<\/span> per confermarne l'assenza.<\/p>\n

Cheilite Granulomatosa (Granulomatosi Orofacciale):<\/strong> Questa condizione pu\u00f2 risultare istologicamente<\/span> identica alla MCD. In questi casi, le caratteristiche cliniche del paziente sono fondamentali per ottenere una differenziazione precisa.<\/p>\n

La corretta identificazione di questi pattern istopatologici \u00e8 essenziale per guidare la gestione terapeutica della malattia di Crohn metastatica sulla pelle.<\/p>\n<\/section>","protected":false},"excerpt":{"rendered":"

Reglas Absolutas de la Enfermedad de Crohn Metast\u00e1sica y su Patolog\u00eda Cut\u00e1nea Los pacientes que padecen la enfermedad de Crohn tienen riesgo de desarrollar **lesiones** cut\u00e1neas est\u00e9riles y granulomatosas fuera del tracto gastrointestinal. Esta manifestaci\u00f3n se denomina Enfermedad de Crohn Metast\u00e1sica (MCD). Cuando afecta espec\u00edficamente a la piel, se le conoce como Enfermedad de Crohn […]<\/p>\n","protected":false},"author":1,"featured_media":7129,"parent":0,"template":"","glossary-cat":[],"class_list":["post-7123","glossary","type-glossary","status-publish","has-post-thumbnail","hentry"],"yoast_head":"\nPatolog\u00eda metast\u00e1sica de la enfermedad de Crohn - Dermatly.com - El sitio de tu piel<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/dermatly.com\/it\/patologia-metastatica-del-morbo-di-crohn\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Patolog\u00eda metast\u00e1sica de la enfermedad de Crohn\" \/>\n<meta property=\"og:description\" content=\"Reglas Absolutas de la Enfermedad de Crohn Metast\u00e1sica y su Patolog\u00eda Cut\u00e1nea Los pacientes que padecen la enfermedad de Crohn tienen riesgo de desarrollar **lesiones** cut\u00e1neas est\u00e9riles y granulomatosas fuera del tracto gastrointestinal. Esta manifestaci\u00f3n se denomina Enfermedad de Crohn Metast\u00e1sica (MCD). Cuando afecta espec\u00edficamente a la piel, se le conoce como Enfermedad de Crohn […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/dermatly.com\/it\/patologia-metastatica-del-morbo-di-crohn\/\" \/>\n<meta property=\"og:site_name\" content=\"Dermatly.com - El sitio de tu piel\" \/>\n<meta property=\"article:modified_time\" content=\"2026-03-10T16:06:18+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/dermatly.com\/wp-content\/uploads\/2020\/11\/metastatic-crohn-figure1__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDBd-4115011.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"294\" \/>\n\t<meta property=\"og:image:height\" content=\"222\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Tempo di lettura stimato\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minuti\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/dermatly.com\/patologia-metastasica-de-la-enfermedad-de-crohn\/\",\"url\":\"https:\/\/dermatly.com\/patologia-metastasica-de-la-enfermedad-de-crohn\/\",\"name\":\"Patolog\u00eda metast\u00e1sica de la enfermedad de Crohn - Dermatly.com - El sitio de tu piel\",\"isPartOf\":{\"@id\":\"https:\/\/dermatly.com\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/dermatly.com\/patologia-metastasica-de-la-enfermedad-de-crohn\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/dermatly.com\/patologia-metastasica-de-la-enfermedad-de-crohn\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/dermatly.com\/wp-content\/uploads\/2020\/11\/metastatic-crohn-figure1__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDBd-4115011.jpg\",\"datePublished\":\"2020-11-14T02:57:21+00:00\",\"dateModified\":\"2026-03-10T16:06:18+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/dermatly.com\/patologia-metastasica-de-la-enfermedad-de-crohn\/#breadcrumb\"},\"inLanguage\":\"it-IT\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/dermatly.com\/patologia-metastasica-de-la-enfermedad-de-crohn\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"it-IT\",\"@id\":\"https:\/\/dermatly.com\/patologia-metastasica-de-la-enfermedad-de-crohn\/#primaryimage\",\"url\":\"https:\/\/dermatly.com\/wp-content\/uploads\/2020\/11\/metastatic-crohn-figure1__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDBd-4115011.jpg\",\"contentUrl\":\"https:\/\/dermatly.com\/wp-content\/uploads\/2020\/11\/metastatic-crohn-figure1__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDBd-4115011.jpg\",\"width\":294,\"height\":222,\"caption\":\"metastatic-crohn-figure1__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildbd-4115011-6288138-jpg-8269260\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/dermatly.com\/patologia-metastasica-de-la-enfermedad-de-crohn\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/dermatly.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Glossary\",\"item\":\"https:\/\/dermatly.com\/glossary\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Patolog\u00eda metast\u00e1sica de la enfermedad de Crohn\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/dermatly.com\/#website\",\"url\":\"https:\/\/dermatly.com\/\",\"name\":\"Dermatly.com - El sitio de tu piel\",\"description\":\"Dermatolog\u00eda y lesiones de la piel\",\"publisher\":{\"@id\":\"https:\/\/dermatly.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/dermatly.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"it-IT\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/dermatly.com\/#organization\",\"name\":\"dermatly.com\",\"url\":\"https:\/\/dermatly.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"it-IT\",\"@id\":\"https:\/\/dermatly.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/dermatly.com\/wp-content\/uploads\/2020\/11\/dermatly-logo.png\",\"contentUrl\":\"https:\/\/dermatly.com\/wp-content\/uploads\/2020\/11\/dermatly-logo.png\",\"width\":448,\"height\":110,\"caption\":\"dermatly.com\"},\"image\":{\"@id\":\"https:\/\/dermatly.com\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Patologia metastatica del morbo di Crohn - Dermatly.com - Il sito della tua pelle","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/dermatly.com\/it\/patologia-metastatica-del-morbo-di-crohn\/","og_locale":"it_IT","og_type":"article","og_title":"Patolog\u00eda metast\u00e1sica de la enfermedad de Crohn","og_description":"Reglas Absolutas de la Enfermedad de Crohn Metast\u00e1sica y su Patolog\u00eda Cut\u00e1nea Los pacientes que padecen la enfermedad de Crohn tienen riesgo de desarrollar **lesiones** cut\u00e1neas est\u00e9riles y granulomatosas fuera del tracto gastrointestinal. Esta manifestaci\u00f3n se denomina Enfermedad de Crohn Metast\u00e1sica (MCD). Cuando afecta espec\u00edficamente a la piel, se le conoce como Enfermedad de Crohn […]","og_url":"https:\/\/dermatly.com\/it\/patologia-metastatica-del-morbo-di-crohn\/","og_site_name":"Dermatly.com - El sitio de tu piel","article_modified_time":"2026-03-10T16:06:18+00:00","og_image":[{"width":294,"height":222,"url":"https:\/\/dermatly.com\/wp-content\/uploads\/2020\/11\/metastatic-crohn-figure1__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDBd-4115011.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_misc":{"Tempo di lettura stimato":"2 minuti"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/dermatly.com\/patologia-metastasica-de-la-enfermedad-de-crohn\/","url":"https:\/\/dermatly.com\/patologia-metastasica-de-la-enfermedad-de-crohn\/","name":"Patologia metastatica del morbo di Crohn - Dermatly.com - Il sito della tua pelle","isPartOf":{"@id":"https:\/\/dermatly.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/dermatly.com\/patologia-metastasica-de-la-enfermedad-de-crohn\/#primaryimage"},"image":{"@id":"https:\/\/dermatly.com\/patologia-metastasica-de-la-enfermedad-de-crohn\/#primaryimage"},"thumbnailUrl":"https:\/\/dermatly.com\/wp-content\/uploads\/2020\/11\/metastatic-crohn-figure1__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDBd-4115011.jpg","datePublished":"2020-11-14T02:57:21+00:00","dateModified":"2026-03-10T16:06:18+00:00","breadcrumb":{"@id":"https:\/\/dermatly.com\/patologia-metastasica-de-la-enfermedad-de-crohn\/#breadcrumb"},"inLanguage":"it-IT","potentialAction":[{"@type":"ReadAction","target":["https:\/\/dermatly.com\/patologia-metastasica-de-la-enfermedad-de-crohn\/"]}]},{"@type":"ImageObject","inLanguage":"it-IT","@id":"https:\/\/dermatly.com\/patologia-metastasica-de-la-enfermedad-de-crohn\/#primaryimage","url":"https:\/\/dermatly.com\/wp-content\/uploads\/2020\/11\/metastatic-crohn-figure1__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDBd-4115011.jpg","contentUrl":"https:\/\/dermatly.com\/wp-content\/uploads\/2020\/11\/metastatic-crohn-figure1__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDBd-4115011.jpg","width":294,"height":222,"caption":"metastatic-crohn-figure1__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildbd-4115011-6288138-jpg-8269260"},{"@type":"BreadcrumbList","@id":"https:\/\/dermatly.com\/patologia-metastasica-de-la-enfermedad-de-crohn\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/dermatly.com\/"},{"@type":"ListItem","position":2,"name":"Glossary","item":"https:\/\/dermatly.com\/glossary\/"},{"@type":"ListItem","position":3,"name":"Patolog\u00eda metast\u00e1sica de la enfermedad de Crohn"}]},{"@type":"WebSite","@id":"https:\/\/dermatly.com\/#website","url":"https:\/\/dermatly.com\/","name":"Dermatly.com - Il sito per la tua pelle","description":"Dermatologia e lesioni cutanee","publisher":{"@id":"https:\/\/dermatly.com\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/dermatly.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"it-IT"},{"@type":"Organization","@id":"https:\/\/dermatly.com\/#organization","name":"dermatly.com","url":"https:\/\/dermatly.com\/","logo":{"@type":"ImageObject","inLanguage":"it-IT","@id":"https:\/\/dermatly.com\/#\/schema\/logo\/image\/","url":"https:\/\/dermatly.com\/wp-content\/uploads\/2020\/11\/dermatly-logo.png","contentUrl":"https:\/\/dermatly.com\/wp-content\/uploads\/2020\/11\/dermatly-logo.png","width":448,"height":110,"caption":"dermatly.com"},"image":{"@id":"https:\/\/dermatly.com\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/dermatly.com\/it\/wp-json\/wp\/v2\/glossary\/7123","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dermatly.com\/it\/wp-json\/wp\/v2\/glossary"}],"about":[{"href":"https:\/\/dermatly.com\/it\/wp-json\/wp\/v2\/types\/glossary"}],"author":[{"embeddable":true,"href":"https:\/\/dermatly.com\/it\/wp-json\/wp\/v2\/users\/1"}],"version-history":[{"count":2,"href":"https:\/\/dermatly.com\/it\/wp-json\/wp\/v2\/glossary\/7123\/revisions"}],"predecessor-version":[{"id":24511,"href":"https:\/\/dermatly.com\/it\/wp-json\/wp\/v2\/glossary\/7123\/revisions\/24511"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dermatly.com\/it\/wp-json\/wp\/v2\/media\/7129"}],"wp:attachment":[{"href":"https:\/\/dermatly.com\/it\/wp-json\/wp\/v2\/media?parent=7123"}],"wp:term":[{"taxonomy":"glossary-cat","embeddable":true,"href":"https:\/\/dermatly.com\/it\/wp-json\/wp\/v2\/glossary-cat?post=7123"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}