{"id":7496,"date":"2020-11-14T08:26:30","date_gmt":"2020-11-14T08:26:30","guid":{"rendered":"https:\/\/dermatly.com\/carcinoma-cutaneo-de-celulas-escamosas\/"},"modified":"2026-03-15T11:25:59","modified_gmt":"2026-03-15T11:25:59","slug":"squamous-cell-carcinoma","status":"publish","type":"glossary","link":"https:\/\/dermatly.com\/en\/carcinoma-cutaneo-de-celulas-escamosas\/","title":{"rendered":"Squamous Cell Carcinoma of the Skin"},"content":{"rendered":"
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Cutaneous Squamous Cell Carcinoma: Definition and Understanding<\/h1>\n

Cutaneous squamous cell carcinoma (SCC) is classified as a common type of keratinocyte cancer, keratinocytes<\/span>, or a non-melanoma skin cancer. melanoma<\/span>. This tumor originates in the epidermal cells epidermis<\/span> responsible for producing keratin<\/span>, the essential fibrous protein that forms the structure of the skin, hair, and nails. hair<\/span> and and nail<\/span>.<\/p>\n

Cutaneous SCC is an invasive<\/span>, condition, meaning the malignant cells have breached the boundary of the epidermis. While SCC can metastasize<\/span>, which represents a life-threatening risk, there are subtypes that are managed differently.<\/p>\n

Other related diagnoses include intraepidermal squamous cell carcinoma (SCC in situ<\/span>in situ mucosa<\/span>, ) and mucosal SCCs, which are evaluated separately.<\/p>\n

Who is at Risk for Cutaneous Squamous Cell Carcinoma?<\/h2>\n

Susceptibility to cutaneous squamous cell carcinoma is linked to several key risk factors, primarily related to cumulative sun exposure:<\/p>\n

    \n
  • Demographics:<\/strong> SCCs are notoriously more prevalent<\/span> in older men, although they also affect women and younger individuals.<\/li>\n
  • Cancer History:<\/strong> Having previously had SCC or other types of skin cancer, such as basal cell carcinoma basal cell<\/span> or melanoma, significantly increases future risk.<\/li>\n
  • Pre-cancerous Lesions:<\/strong> The presence of actinic keratosis<\/span> The presence of actinic keratosis.<\/li>\n
  • Environmental Exposure:<\/strong> Occupations or recreational activities that involve prolonged outdoor exposure.<\/li>\n
  • Lifestyle Habits:<\/strong> Tobacco use is a known risk factor.<\/li>\n
  • Physical Characteristics:<\/strong> Fair skin, blue eyes, and blond or red hair.<\/li>\n
  • History of Skin Damage:<\/strong> Previous conditions such as leg ulcers (ulcer), cutaneous lupus, or epidermolysis bullosa.ulcer<\/span>, cutaneous lupus, or epidermolysis bullosa.<\/li>\n
  • Genetic Factors:<\/strong> Rare hereditary syndromes, such as albinism and xeroderma pigmentosum, increase vulnerability.<\/li>\n
  • Immunosuppression:<\/strong> Suppression of the immune system, whether due to diseases like chronic lymphocytic leukemia, leukemia<\/span> lymphocytic<\/span> chronic<\/span>, or by medication (common in organ transplant recipients transplantation<\/span> ), drastically increases the risk of SCC. Arsenic and exposure to ionizing radiation are also included here.<\/li>\n<\/ul>\n
    <\/div>\n

    Molecular Causes of Cutaneous Squamous Cell Carcinoma<\/h2>\n

    In over 90% of SCC cases, multiple DNA mutations are identified mutations<\/span> of the DNA<\/span> distributed across various fundamental somatic genes<\/span> . A predominant cause of these genetic alterations is exposure to ultraviolet (UV) radiation ultraviolet radiation<\/span> (UV<\/span>), particularly the UVB band, which is reflected in the \u00absignature 7\u00bb of mutations affecting the gene<\/span> tumor suppressor p53 gene.<\/p>\n

    Other characteristic mutations are associated with the aging process, smoking, and the state of Obesity.<\/span> immunosuppression receptor<\/span> of the and insulin-like<\/span> epidermal<\/span>, induced by drugs such as azathioprine. At the signaling pathway level, alterations are observed in the epidermal growth factor receptor.<\/p>\n

    , as well as in the RAS, Fyn, and p16INK4a cascades.<\/p>\n<\/section>\n

    \u00ab`html<\/p>\n

    Additionally, the involvement of beta-genus human papillomaviruses in the etiology of these skin tumors is being investigated.<\/p>\n

    Clinical Features of Cutaneous Squamous Cell Carcinoma<\/h2>\n

    The manifestations of cutaneous SCC are typically characterized by scaly nodules or papillomas.<\/strong> o crusted<\/strong> growths. Commonly, these lesions emerge over areas of pre-existing actinic keratosis<\/strong> actinic keratosis or intraepidermal carcinomas.<\/p>\n

      \n
    • They grow progressively over weeks or months.<\/li>\n
    • Ulceration is possible.<\/li>\n
    • They frequently present with tenderness or pain upon palpation.<\/li>\n
    • They are located in areas of high sun exposure, notably the face, lips, ears, hands, forearms, and calves.<\/li>\n
    • The diameter of the lesions is variable, ranging from a few millimeters to several centimeters.<\/li>\n<\/ul>\n
      \n
      Visual Examples of Squamous Cell Carcinoma<\/h5>\n<\/section>\n
      \n
      \n
      \"Specimen<\/div>\n

      Squamous cell carcinoma<\/p>\n

      \"Squamous<\/div>\n

      Squamous cell carcinoma<\/p>\n

      \"Advanced<\/div>\n

      Squamous cell carcinoma<\/p>\n<\/div>\n<\/section>\n

      <\/div>\n

      For a more detailed exploration of clinical presentations, you can consult specific images of SCCs located on:<\/p>\n

        \n
      • The face<\/li>\n
      • The lip<\/li>\n
      • The ear<\/li>\n
      • The extremities.<\/li>\n<\/ul>\n

        Classification and Types of Cutaneous Squamous Cell Carcinoma<\/h2>\n

        Invasive cutaneous SCC is subdivided into several distinct clinical types, which include:<\/p>\n

          \n
        • Cutaneous horn:<\/strong> Characterized by excessive keratin production forming a hard, horn-like protrusion.<\/li>\n
        • Keratoacanthoma (KA):<\/strong> A rapidly developing keratinizing nodule that may occasionally regress spontaneously without intervention.<\/li>\n
        • Carcinoma cuniculatum or verrucous carcinoma:<\/strong> A slow-growing, wart-like tumor that manifests predominantly on the sole of the foot.<\/li>\n
        • Multiple SCC\/KA type lesions:<\/strong> Rashes that appear in the context of specific syndromes, such as Ferguson-Smith multiple self-healing squamous epitheliomas and Grzybowski syndrome.<\/li>\n<\/ul>\n

          Additionally, the pathologist evaluates the microscopic appearance to classify the tumor as well- differentiated<\/strong>, differentiated anaplastic).<\/strong>. , moderately well-differentiated, poorly differentiated, or anaplastic. There are other less common histological variants that must also be considered in the diagnosis.<\/p>\n

          \n
          Histopathological Subtypes of Cutaneous Carcinoma<\/h5>\n<\/section>\n
          \n
          \n
          \"Example<\/div>\n

          Cutaneous Horn<\/p>\n

          \"Large<\/div>\n

          Keratoacanthoma<\/p>\n<\/div>\n<\/section>\n

          Accurately determining the type and degree of differentiation of Squamous Cell Carcinoma is fundamental, as it directly influences the prognosis and the most appropriate treatment strategy for the patient.<\/p>\n

          \u00ab`<\/p>\n

          \"Example
          Carcinoma Cuniculatum<\/figcaption><\/figure>\n
          \"Example
          Ferguson-Smith squamous epithelioma<\/figcaption><\/figure>\n
          \"Illustrative
          Grzybowski Syndrome<\/figcaption><\/figure>\n
          <\/div>\n
          <\/div>\n

          Classification of Squamous Cell Carcinoma by Progression Risk<\/h2>\n

          Cutaneous Squamous Cell Carcinoma (SCC) is stratified into low- or high-risk categories, based on the tumor's recurrence susceptibility and the potential to develop Benefits of Germline Genetic Testing for Melanoma<\/span>. metastasis. Lesions classified as high-risk present the following clinical and histological characteristics:<\/p>\n

          High-risk cutaneous squamous cell carcinoma exhibits the following distinctive characteristics:<\/p>\n

            \n
          • Lesion diameter equal to or greater than 2 cm.<\/li>\n
          • Location in key anatomical areas: ear, lip vermilion, central face, hands, feet, or genitals.<\/li>\n
          • Origin in patients characterized by advanced age or significant immunosuppression.<\/li>\n
          • Musculoskeletal histological<\/span> Histological findings histology<\/span> histology, or demonstrable invasion into subcutaneous tissue, nerves, or blood vessels. subcutaneously<\/span>, nerves<\/span> o blood vessels<\/span>.<\/li>\n<\/ul>\n

            Metastatic SCC metastatic<\/span> lymph nodes Cetirizine<\/span> in regional nodes (80% of cases), but can also affect the lungs, liver, brain, bones, and other cutaneous sites.<\/p>\n

            \n
            Manifestations of High-Risk Cutaneous Squamous Cell Carcinoma<\/h5>\n<\/section>\n
            \n
            \n
            \"Image
            High-risk cutaneous squamous cell carcinoma<\/figcaption><\/figure>\n
            \"Another
            High-risk cutaneous squamous cell carcinoma<\/figcaption><\/figure>\n
            \"Visual
            High-risk cutaneous squamous cell carcinoma<\/figcaption><\/figure>\n<\/div>\n<\/section>\n
            <\/div>\n

            Staging of Cutaneous Squamous Cell Carcinoma according to AJCC<\/h2>\n

            In 2011, the American Joint Committee on Cancer (AJCC) introduced new systemic staging guidelines systemic sclerosis)<\/span> for cutaneous SCC, specifically in the 7th edition of its manual. This system comprehensively evaluates the dimensions of the primary tumor primary<\/span> (T) and the presence of Benefits of Germline Genetic Testing for Melanoma<\/span> metastasis.<\/p>\n

            Tumor Classification (T) for Cutaneous SCC<\/h3>\n

            TX: The primary tumor cannot be adequately assessed.<\/p>\n

            Classification and Management of Cutaneous Squamous Cell Carcinoma<\/h1>\n

            T0: Absence of evident primary tumor<\/p>\n

            Tis: Carcinoma in situ<\/p>\n

            T1: Tumor \u2264 2 cm without high-risk features<\/p>\n

            T2: Tumor \u2265 2 cm; OR, Tumor \u2264 2 cm with high-risk features<\/p>\n

            T3: Tumor with invasion of the maxilla<\/span>, temporal bone<\/span> or the orbit<\/p>\n

            T4: Tumor with invasion of the axial<\/span> or appendicular skeleton, or perineural<\/span> invasion of the skull base<\/p>\n

            Lymphatic Staging for Cutaneous Squamous Cell Carcinoma (SCC)<\/h2>\n

            NX: Regional lymph nodes cannot be assessed<\/p>\n

            N0: No metastasis in regional lymph nodes<\/span> lymph nodes<\/p>\n

            N1: Metastasis in one local lymph node \u2264 3 cm<\/p>\n

            N2: Metastasis in one local lymph node \u2265 3 cm; OR, Metastasis in more than 1 local lymph node \u2264 6 cm<\/p>\n

            N3: Metastasis in a lymph node \u2265 6 cm<\/p>\n

            Diagnostic Methods for Squamous Cell Carcinoma<\/h2>\n

            The initial diagnosis of cutaneous SCC is established based on observable clinical characteristics. Diagnostic confirmation and determination of the histological subtype are obtained through pathological analysis after a biopsy<\/span> biopsy removal<\/span>. or pathology<\/span> following excision. Consult the section on cutaneous cell carcinoma pathology for more details.<\/p>\n

            Patients diagnosed with high-risk SCC should undergo staging studies to determine if the disease has spread to the lymph nodes or other areas. These evaluations may include:<\/p>\n

              \n
            • Imaging studies, such as ultrasound.<\/span>, ultrasound CT (Computed Tomography): This scan shows exclusive skin thickening in cases of lipedema. In lymphedema, in contrast, fluid accumulation, a characteristic honeycomb pattern, and possible muscle enlargement are observed.<\/span> , X-rays, CT scans CT<\/span> or Magnetic Resonance Imaging (MRI).<\/li>\n
            • Biopsies<\/span> (Computed Tomography) or MRI scans. Lymph node biopsies.<\/li>\n<\/ul>\n

              Treatment Options for Cutaneous Squamous Cell Carcinoma<\/h2>\n

              Treatment for cutaneous SCC is predominantly surgical. Generally, excision is performed with a margin of 3 to 10 mm of healthy tissue around the visible tumor. Occasionally, a flap or skin graft may be necessary to restore the integrity of the treated area.<\/p>\n

              Other removal techniques include the following specialized options:<\/p>\n

                \n
              • Scraping, curettage, and electrocautery for low-risk tumors located on the trunk and extremities.<\/li>\n
              • Cryotherapy<\/span> Aggressive cryotherapy.<\/li>\n
              • applied to very small, thin tumors with a low risk of progression. Mohs micrographic surgery, ideal for extensive facial lesions with poorly defined margins or for recurrent tumors. areas), as well as the hands, feet, and genitals. It can also involve the tongue, uvula, soft palate, and<\/span>.<\/li>\n
              • Radiation therapy<\/span> Radiotherapy adjuvant<\/span>.<\/li>\n<\/ul>\n

                is indicated when the tumor is inoperable, in patients unfit for surgery, or as adjuvant treatment.<\/h2>\n

                Management of Advanced or Metastatic Squamous Cell Carcinoma multidisciplinary<\/span>. Locally advanced SCC (whether primary, recurrent, or metastatic) demands a multidisciplinary approach. Frequently, a strategic combination of various therapies is required:<\/p>\n

                  \n
                • Surgery.<\/li>\n
                • Radiotherapy.<\/li>\n
                • Cemiplimab (an immunotherapy).<\/li>\n
                • Targeted therapy<\/span> Experimental targeted therapy and<\/span> using epidermal growth factor receptor inhibitors.<\/li>\n<\/ul>\n

                  Each year, thousands of people in New Zealand receive treatment for cutaneous SCC, and unfortunately, over 100 die from this condition.<\/p>\n

                  Preventive Strategies for Cutaneous Squamous Cell Carcinoma<\/h2>\n

                  There is solid evidence supporting that rigorous and consistent lifelong sun protection significantly reduces the incidence of SCC. This is crucial for individuals with fair, aged, or sun-damaged skin; for immunosuppressed patients; and for those with a history of actinic keratoses or previous SCCs.<\/p>\n

                  Key preventive measures include:<\/p>\n

                    \n
                  • Staying indoors or seeking shade during peak sun hours (midday).<\/li>\n
                  • Wearing protective clothing that covers most of the body.<\/li>\n
                  • Generously applying broad-spectrum sunscreens with a high sun protection factor (SPF) (SPF50+) to all exposed skin exposed skin<\/span> when outdoors.<\/li>\n
                  • Strictly avoiding tanning beds and indoor sun lamps.<\/li>\n<\/ul>\n

                    Oral nicotinamide (vitamin B3) administration at a dose of 500 mg twice daily has shown the ability to decrease both the number and severity of SCCs in individuals considered high-risk.<\/p>\n

                    Patients with multiple carcinomas<\/span> squamous cell In approximately 25% of patients, it is necessary to add a complementary therapeutic agent to the initial regimen. These additional agents include:<\/span> carcinomas may be prescribed an oral retinoid (such as acitretin or isotretinoin). These drugs reduce the appearance of new tumors, although they carry some side effects that must be managed.<\/p>\n

                    Prognosis and Outlook for Cutaneous Squamous Cell Carcinoma<\/h2>\n

                    Most SCC cases are successfully cured through timely treatment. The probability of cure increases considerably when the lesion is detected and treated in early stages. However, the risk of recurrence or disease-related death is higher for tumors measuring more than 20 mm in diameter or thicker than 2 mm at the time of surgical excision.<\/p>\n

                    Approximately 50% of people at high risk for SCC or will<\/span> will develop a second tumor within 5 years of the first. This group also has an elevated risk of developing other types of skin cancer, particularly melanoma. Therefore, periodic skin self-examinations and long-term annual skin checks by an expert healthcare professional are strongly advised.<\/p>","protected":false},"excerpt":{"rendered":"

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Este tumor se origina en las c\u00e9lulas de la epidermis responsables de producir queratina, la prote\u00edna fibrosa esencial que forma la estructura de la piel, el cabello […]<\/p>\n","protected":false},"author":1,"featured_media":409,"parent":0,"template":"","glossary-cat":[],"class_list":["post-7496","glossary","type-glossary","status-publish","has-post-thumbnail","hentry"],"yoast_head":"\nCarcinoma cut\u00e1neo de c\u00e9lulas escamosas - Dermatly.com - El sitio de tu piel<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/dermatly.com\/en\/squamous-cell-carcinoma\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Carcinoma cut\u00e1neo de c\u00e9lulas escamosas\" \/>\n<meta property=\"og:description\" content=\"Carcinoma Escamoso Cut\u00e1neo: Definici\u00f3n y Entendimiento El carcinoma escamoso cut\u00e1neo (SCC) se clasifica como un tipo frecuente de c\u00e1ncer de queratinocitos, o un c\u00e1ncer de piel no melanoma. 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