{"id":4152,"date":"2020-11-11T02:45:13","date_gmt":"2020-11-11T02:45:13","guid":{"rendered":"https:\/\/dermatly.com\/patologia-del-penfigoide-bulloso\/"},"modified":"2026-03-10T10:12:32","modified_gmt":"2026-03-10T10:12:32","slug":"bullous-pemphigoid-pathology","status":"publish","type":"glossary","link":"https:\/\/dermatly.com\/en\/patologia-del-penfigoide-bulloso\/","title":{"rendered":"Pathology of Bullous Pemphigoid"},"content":{"rendered":"<section class=\"textBlock\">\n<p><span class=\"term\" data-term-id=\"498\">Bulloso<\/span> penfigoide es el m\u00e1s com\u00fan <span class=\"term\" data-term-id=\"691\">autoinmune<\/span> <span class=\"term\" data-term-id=\"60\">dermatosis<\/span> presentando cultivos de tiempo <span class=\"term\" data-term-id=\"244\">pruriginoso<\/span> ampollas, a menudo en adultos mayores. <span class=\"term\" data-term-id=\"1018\">Mucosa<\/span> puede ocurrir afectaci\u00f3n y existen varios subtipos cl\u00ednicos. <span class=\"term\" data-term-id=\"352\">Autoanticuerpos<\/span> se dirigen a los componentes del <span class=\"term\" data-term-id=\"1970\">membrana basal<\/span>, particularmente el BP <span class=\"term\" data-term-id=\"411\">ant\u00edgenos<\/span> BP180 y BP230.<\/p>\n<h2><span class=\"term\" data-term-id=\"128\">Histolog\u00eda<\/span> de penfigoide bulloso<\/h2>\n<p>Temprano <span class=\"term\" data-term-id=\"2115\">lesiones<\/span> durante el <span class=\"term\" data-term-id=\"293\">urticaria<\/span> fase puede ser inespec\u00edfica y mostrar leve superior <span class=\"term\" data-term-id=\"52\">d\u00e9rmico<\/span> <span class=\"term\" data-term-id=\"201\">edema<\/span> con <span class=\"term\" data-term-id=\"228\">perivascular<\/span> <span class=\"term\" data-term-id=\"541\">infiltrado<\/span> (Figura 1).  A menudo son conspicuos <span class=\"term\" data-term-id=\"448\">eosin\u00f3filos<\/span>. <span class=\"term\" data-term-id=\"142\">Inmunofluorescencia<\/span> es muy \u00fatil en esta fase inicial.<\/p>\n<p>Blister establecido: el blister es <span class=\"term\" data-term-id=\"2429\">subepid\u00e9rmico<\/span> y contiene <span class=\"term\" data-term-id=\"850\">fibrina<\/span> y un gran n\u00famero de <span class=\"term\" data-term-id=\"490\">inflamatorio<\/span> c\u00e9lulas que incluyen eosin\u00f3filos (figuras 2, 3).  Los eosin\u00f3filos pueden ser muy densos en \u00e1reas y formar peque\u00f1as <span class=\"term\" data-term-id=\"1937\">abscesos<\/span> en lo superficial <span class=\"term\" data-term-id=\"61\">dermis<\/span>.<\/p>\n<section class=\"textBlock imageLinkBlockTitle\">\n<h5 class=\"colour--primary\">Patolog\u00eda del penfigoide bulloso<\/h5>\n<\/section>\n<section class=\"imageLinkBlock\">\n<div class=\"flex\">\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img decoding=\"async\" src=\"https:\/\/dermatly.com\/wp-content\/uploads\/2020\/11\/bullous-pemphigoid-figure1__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd.jpg\" alt=\"Patolog\u00eda del penfigoide bulloso\"><\/div>\n<p class=\"p-small\">Figura 1<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img decoding=\"async\" src=\"https:\/\/dermatly.com\/wp-content\/uploads\/2020\/11\/bullous-pemphigoid-figure-2__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd.jpg\" alt=\"Patolog\u00eda del penfigoide bulloso\"><\/div>\n<p class=\"p-small\">Figura 2<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img decoding=\"async\" src=\"https:\/\/dermatly.com\/wp-content\/uploads\/2020\/11\/bp-figure-3__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd.jpg\" alt=\"Patolog\u00eda del penfigoide bulloso\"><\/div>\n<p class=\"p-small\">figura 3<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img decoding=\"async\" src=\"https:\/\/dermatly.com\/wp-content\/uploads\/2020\/11\/bullous-pemphigoid-figure4__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd.jpg\" alt=\"Patolog\u00eda del penfigoide bulloso\"><\/div>\n<p class=\"p-small\">Figura 4<\/p>\n<\/p><\/div>\n<\/section>\n<div class=\"clearfix imageLinkBlock\"><\/div>\n<h2>Estudios especiales de penfigoide bulloso<\/h2>\n<p>Muestras de inmunofluorescencia directa <span class=\"term\" data-term-id=\"321\">lineal<\/span> <span class=\"term\" data-term-id=\"370\">declaraci\u00f3n<\/span> de IgG (m\u00e1s a menudo subtipo IgG4) y C3 a lo largo de la membrana basal (figura 4).  Los estudios de inmunofluorescencia indirecta de piel dividida generalmente no son necesarios, pero pueden ser \u00fatiles en casos raros cuando se sospecha epiderm\u00f3lisis bullosa aquisita.<\/p>\n<div id=\"square-placement-country-holder\" class=\"country-dependent advert\">\n<div class=\"box-placement square-placement\">\n<div class=\"advert__frame\">\n                        <!-- \/340621630\/dermnet_mobile_afterfirstsection_300x250 --><\/p>\n<div style=\"display: none;\" id=\"hidden-div-gpt-ad-1484122037505-8\" class=\"[ js-hideable ]\"><\/div>\n<p><script>\n    if (ads_screenwidth < 780 ) {\n        var inline = document.createElement(\"div\");\n        var ad = document.createElement(\"div\");\n\n        ad.id = 'div-gpt-ad-1484122037505-8';\n        ad.style.height=\"250px\";\n        ad.style.width=\"300px;\";\n\n        inline.appendChild(ad);\n        inline.className = \"inline\";\n        var placeholder = document.getElementById(\"hidden-div-gpt-ad-1484122037505-8\");\n        placeholder.parentNode.replaceChild(inline, placeholder);\n        (function () {\n            googletag.cmd.push(function () {\n                googletag.display('div-gpt-ad-1484122037505-8');\n            });\n        })();\n    }\n<\/script>\n                    <\/div>\n<\/p><\/div>\n<\/p><\/div>\n<h2><span class=\"term\" data-term-id=\"813\">Diagn\u00f3stico diferencial<\/span> de penfigoide bulloso<\/h2>\n<p><span class=\"term\" data-term-id=\"53\">Dermatitis<\/span> herpetiforme: <span class=\"term\" data-term-id=\"441\">Neutr\u00f3filos<\/span> papilar d\u00e9rmico <span class=\"term\" data-term-id=\"1454\">microabscesos<\/span> que se observan en la dermatitis herpetiforme no suelen estar presentes en el penfigoide bulloso, pero pueden estar presentes en algunas variantes.  Muestras de inmunofluorescencia directa <span class=\"term\" data-term-id=\"2355\">granular<\/span> deposici\u00f3n de IgA.<\/p>\n<p>Enfermedad por IgA lineal: formaci\u00f3n de ampollas subepid\u00e9rmicas con dep\u00f3sito lineal de IgA en la membrana basal por inmunofluorescencia directa.<\/p>\n<p>Epiderm\u00f3lisis ampollosa aquisita muestra subepid\u00e9rmica <span class=\"term\" data-term-id=\"499\">bullae<\/span> con deposici\u00f3n lineal de IgG \/ C3, sin embargo, la inmunofluorescencia indirecta en estas condiciones revela positividad en el piso de la piel dividida, mientras que el penfigoide ampolloso tiene positividad en el <span class=\"term\" data-term-id=\"846\">epid\u00e9rmico<\/span> lado.<\/p>\n<p>Otras causas de ampollas subepid\u00e9rmicas incluyen epiderm\u00f3lisis ampollosa, <span class=\"term\" data-term-id=\"2219\">porfiria<\/span> cut\u00e1nea tarda y ampollosa <span class=\"term\" data-term-id=\"1949\">amilosis<\/span>.<\/p>\n<\/section>\n","protected":false},"excerpt":{"rendered":"<p>Bulloso penfigoide es el m\u00e1s com\u00fan autoinmune dermatosis presentando cultivos de tiempo pruriginoso ampollas, a menudo en adultos mayores. Mucosa puede ocurrir afectaci\u00f3n y existen varios subtipos cl\u00ednicos. Autoanticuerpos se dirigen a los componentes del membrana basal, particularmente el BP ant\u00edgenos BP180 y BP230. Histolog\u00eda de penfigoide bulloso Temprano lesiones durante el urticaria fase puede [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":4157,"parent":0,"template":"","glossary-cat":[],"class_list":["post-4152","glossary","type-glossary","status-publish","has-post-thumbnail","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.2 (Yoast SEO v27.1.1) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Patolog\u00eda del penfigoide bulloso - Dermatly.com - El sitio de tu piel<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/dermatly.com\/en\/bullous-pemphigoid-pathology\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Patolog\u00eda del penfigoide bulloso\" \/>\n<meta property=\"og:description\" content=\"Bulloso penfigoide es el m\u00e1s com\u00fan autoinmune dermatosis presentando cultivos de tiempo pruriginoso ampollas, a menudo en adultos mayores. 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